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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1985-6-28
|
| pubmed:abstractText |
Between July 1979 and May 1982, we treated 45 male patients with refractory germinal neoplasms. All patients had previously received intensive cisplatin-containing combination chemotherapy regimens. Patients received salvage chemotherapy with VP-16 and cisplatin +/- bleomycin +/- doxorubicin. Of 44 evaluable patients, 19 (43%) achieved complete remissions with salvage chemotherapy, 12 (27%) had partial remissions, and nine (21%) had no response. Four patients (9%) were not evaluable for response due to early death or noncompliance but are considered treatment failures. Ten patients (23%) remain alive and continuously disease free 20 to 39 months (median, 29 months) after completion of therapy. Hematologic toxicity was severe, with one death related to sepsis. Bleomycin-induced pulmonary fibrosis occurred in 17 patients with two fatalities. The addition of bleomycin and/or doxorubicin to this regimen increases toxicity and probably does not improve treatment results. Salvage chemotherapy with VP-16 and cisplatin offers potentially curative therapy to men with resistant germinal tumors.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0732-183X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
3
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
666-71
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2582097-Actuarial Analysis,
pubmed-meshheading:2582097-Adolescent,
pubmed-meshheading:2582097-Adult,
pubmed-meshheading:2582097-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:2582097-Bleomycin,
pubmed-meshheading:2582097-Cisplatin,
pubmed-meshheading:2582097-Clinical Trials as Topic,
pubmed-meshheading:2582097-Doxorubicin,
pubmed-meshheading:2582097-Drug Administration Schedule,
pubmed-meshheading:2582097-Etoposide,
pubmed-meshheading:2582097-Humans,
pubmed-meshheading:2582097-Male,
pubmed-meshheading:2582097-Mediastinal Neoplasms,
pubmed-meshheading:2582097-Middle Aged,
pubmed-meshheading:2582097-Neoplasm Recurrence, Local,
pubmed-meshheading:2582097-Neoplasms, Germ Cell and Embryonal,
pubmed-meshheading:2582097-Pulmonary Fibrosis,
pubmed-meshheading:2582097-Retroperitoneal Neoplasms,
pubmed-meshheading:2582097-Testicular Neoplasms
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
Successful treatment of resistant germinal neoplasms with VP-16 and cisplatin: results of a Southeastern Cancer Study Group trial.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.
|