Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1985-5-23
|
| pubmed:abstractText |
Graft-vs-host reaction (GvHR) induced in (B10.BR X CWB)F1 (BWF1; H-2k/b, Ighb/b) by i.v. injection with CWB (H-2b, Ighb) spleen cells resulted in complete suppression of cytotoxic T lymphocyte (CTL) responsiveness of the F1 host spleen cells (GvHR-associated immunosuppression). In contrast, GvHR induced in BWF1 mice with CSW (H-2b, Ighj; Igh-congenic to CWB) spleen cells did not affect CTL responsiveness of the F1 host spleen cells at all. The BWF1 hosts undergoing the CSW-induced GvHR generated anti-CSW CTL in their spleens, and the subsequent culture of such BWF1 spleen cells with CSW stimulator cells, augmented the CTL activity. The BWF1 anti-CSW CTL lysed both Con A- and LPS-induced splenic blasts from mouse strains carrying the Ighj allele in the context of self H-2Kb. However, determination of the Igh haplotype in the serum IgG and of the susceptibility of the splenic lymphocytes to the BWF1 anti-CSW CTL on backcross mice, which carry either Ighb/j or Ighb/b in the context of H-2b/b or H-2b/k, showed clearly that Ighj and the gene coding for the target antigen for the BWF1 anti-CSW CTL segregated at ratios close to 1:1. The study in which linkage between the gene(s) coding for the target antigen for the BWF1 anti-CSW CTL and H-2 was examined on CWB X (C3H X CWB)F1 backcross mice and (B10.BR X CSW)F1 X B10 mice demonstrated that the gene, most likely a single gene, coding for the target antigen for the BWF1 anti-CSW CTL is located at 8.5 +/- 4.3 cross-over units to the right or left of the H-2 complex. We designated the minor H antigen to be recognized by the BWF1 anti-CSW CTL as H-X+, and we discuss the distinction between the H-X+ locus and the other minor H loci on chromosome 17.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0022-1767
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
134
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2953-9
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:2580009-Animals,
pubmed-meshheading:2580009-Crosses, Genetic,
pubmed-meshheading:2580009-Cytotoxicity, Immunologic,
pubmed-meshheading:2580009-Epitopes,
pubmed-meshheading:2580009-Genetic Code,
pubmed-meshheading:2580009-Genetic Linkage,
pubmed-meshheading:2580009-Graft vs Host Reaction,
pubmed-meshheading:2580009-H-2 Antigens,
pubmed-meshheading:2580009-Immunity, Innate,
pubmed-meshheading:2580009-Immunoglobulin Heavy Chains,
pubmed-meshheading:2580009-Isoantigens,
pubmed-meshheading:2580009-Lymphocyte Activation,
pubmed-meshheading:2580009-Mice,
pubmed-meshheading:2580009-Mice, Inbred AKR,
pubmed-meshheading:2580009-Mice, Inbred C3H,
pubmed-meshheading:2580009-Mice, Inbred CBA,
pubmed-meshheading:2580009-Mice, Inbred DBA,
pubmed-meshheading:2580009-Minor Histocompatibility Loci,
pubmed-meshheading:2580009-Spleen,
pubmed-meshheading:2580009-T-Lymphocytes, Cytotoxic
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
The target minor H antigen for F1 cytotoxic T lymphocytes induced by Igh-congenic parental spleen cells is coded for by gene linked to H-2.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|