Linked Life Data

2579708

Source:http://linkedlifedata.com/resource/pubmed/id/2579708

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1985-4-26
pubmed:abstractText
Dendritic spines have been increasingly implicated as sites for neuronal plasticity. Earlier-theoretical studies of dendritic-spine function have assumed passive membrane, and have consequently predicted that postsynaptic potentials in the dendrite are attenuated when the synapse is located on the spine head rather than on the dendritic shaft. Our studies show that active membrane in the spine head (e.g. voltage-dependent Na+ or Ca2+ channels) can produce amplification rather than attenuation of the postsynaptic potential. The presence and amount of amplification depend on the density of active channels and on the spine-neck resistance. For a given type of spine head, there is an optimal spine-neck resistance; a given change in neck resistance can therefore either increase or decrease the amplitude of postsynaptic potentials. These results support the idea that spines mediate synaptic plasticity and suggest a variety of modulatory mechanisms.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
28
pubmed:volume
325
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
331-5
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Dendritic spines: role of active membrane in modulating synaptic efficacy.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't