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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1985-4-12
|
| pubmed:abstractText |
A series of new 1,4-dihydro-1,2,4-triazolo[4,3-]quinoxaline-1,4-diones has been prepared. These compounds were tested as inhibitors of antigen-induced release of histamine (AIR) in vitro from rat peritoneal mast cells (RMC) and as inhibitors of IgE-mediated rat passive cutaneous anaphylaxis (PCA). Most of this new class of antiallergic agents showed good activity in the RMC and PCA tests. The most potent compound, 2-acetyl-7-chloro-5-n-propyl-1,2,4-triazolo[4,3-a]quinoxaline-1,4-dione (1x), with an I50 value of 0.1 microM, is 30 times more potent than disodium cromoglycate (DSCG) in the RMC assay.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0022-2623
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
28
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
363-6
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2579236-Animals,
pubmed-meshheading:2579236-Histamine H1 Antagonists,
pubmed-meshheading:2579236-Histamine Release,
pubmed-meshheading:2579236-Hypersensitivity,
pubmed-meshheading:2579236-Male,
pubmed-meshheading:2579236-Passive Cutaneous Anaphylaxis,
pubmed-meshheading:2579236-Quinoxalines,
pubmed-meshheading:2579236-Rats,
pubmed-meshheading:2579236-Rats, Inbred Strains,
pubmed-meshheading:2579236-Structure-Activity Relationship,
pubmed-meshheading:2579236-Triazoles
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
1,2,4-Triazolo[4,3-a]quinoxaline-1,4-diones as antiallergic agents.
|
| pubmed:publicationType |
Journal Article
|