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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1985-4-19
|
| pubmed:abstractText |
Characteristics of auto-antibodies for carcinoembryonic antigen (CEA) detected in sera from 3 cancer patients (2 colorectal and 1 breast cancer) were examined. The antibodies belonged to polyclonal immunoglobulin G (IgG). The binding of auto-antibodies with the labeled CEA was inhibited by not only the unlabeled CEA but also NCA-2 (feces and meconium). However, no binding with NCA was observed. Among these auto-antibodies the antibody directed against blood group Lewis determinants which are known to be present in many purified CEA preparations was not found. Previously we had suggested that CEA, NCA-2 and NCA may contain immune determinant in common with alpha 1-acid glycoprotein (AG). These auto-antibodies showed significantly enhanced reactivity for the labeled CEA preparation after purification by anti-AG affinity chromatography in spite of no immunological reaction with AG. These results suggest that auto-antibodies are raised against the common antigenic determinants of both CEA and NCA-2 which do not exist in NCA. These antibodies might be directed to common amino acid sequence shared by CEA and NCA-2, though not excluding the carbohydrate moiety. We surveyed about 500,000 cancer patients but could find only 3 patients who showed a difference in the values of CEA by the indirect and direct method. Thus, the existence of this type auto-antibody to CEA in cancer patients is a rare phenomenon.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Carcinoembryonic Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Lewis Blood-Group System
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0304-3835
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
25
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
283-95
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2578868-Aged,
pubmed-meshheading:2578868-Antibodies, Monoclonal,
pubmed-meshheading:2578868-Antibodies, Neoplasm,
pubmed-meshheading:2578868-Antigens, Neoplasm,
pubmed-meshheading:2578868-Autoantibodies,
pubmed-meshheading:2578868-Breast Neoplasms,
pubmed-meshheading:2578868-Carcinoembryonic Antigen,
pubmed-meshheading:2578868-Cell Adhesion Molecules,
pubmed-meshheading:2578868-Colonic Neoplasms,
pubmed-meshheading:2578868-Epitopes,
pubmed-meshheading:2578868-Female,
pubmed-meshheading:2578868-Glycoproteins,
pubmed-meshheading:2578868-Humans,
pubmed-meshheading:2578868-Immunologic Techniques,
pubmed-meshheading:2578868-Lewis Blood-Group System,
pubmed-meshheading:2578868-Liver Neoplasms,
pubmed-meshheading:2578868-Male,
pubmed-meshheading:2578868-Middle Aged,
pubmed-meshheading:2578868-Rectal Neoplasms
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
Studies on circulating antibody against carcinoembryonic antigen (CEA) and CEA-like antigen in cancer patients.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|