|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1985-3-19
|
|
pubmed:abstractText |
Application of a contact-sensitizing agent to the skin of mice previously exposed to UV radiation at a different site results in the induction of hapten-specific suppressor T lymphocytes. When splenic lymphocytes from such mice were cultured with normal lymphocytes and hapten-conjugated splenic adherent cells, the primary proliferative response was suppressed. The cell responsible for the suppression in vitro was a T lymphocyte, and two signals were required for its induction, ultraviolet radiation and hapten sensitization. The T cell suppressing lymphoproliferation was specific for the hapten applied after UV radiation. The UV-induced T suppressor cell inhibited only primary lymphoproliferation; the response of lymphocytes from immunized mice was unaffected. The activity of the UV-induced suppressor cell was not affected by mitomycin C treatment. Thus, suppression of the primary proliferative response of lymphocytes to hapten-modified syngeneic cells in vitro correlates with in vivo suppression of contact hypersensitivity by these UV-induced suppressor cells. This suggests that the suppressor cells act by preventing the proliferation of hapten-specific responder clones. Use of this in vitro assay system should facilitate investigation of the characteristics of these cells and the mechanism by which these regulatory T lymphocytes inhibit contact sensitization.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2578432-1085311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2578432-123935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2578432-15036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2578432-302317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2578432-306405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2578432-4142565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2578432-4279271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2578432-4587740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2578432-4911896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2578432-6156984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2578432-6170721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2578432-6220078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2578432-6223958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2578432-6456650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2578432-6458828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2578432-667953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2578432-68972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2578432-7251064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2578432-87459
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0019-2805
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
54
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
343-52
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:2578432-Animals,
pubmed-meshheading:2578432-Cell Division,
pubmed-meshheading:2578432-Cells, Cultured,
pubmed-meshheading:2578432-Epitopes,
pubmed-meshheading:2578432-Female,
pubmed-meshheading:2578432-Haptens,
pubmed-meshheading:2578432-Hypersensitivity, Delayed,
pubmed-meshheading:2578432-Immune Tolerance,
pubmed-meshheading:2578432-Immunization, Passive,
pubmed-meshheading:2578432-Lymphocyte Activation,
pubmed-meshheading:2578432-Mice,
pubmed-meshheading:2578432-Mice, Inbred C3H,
pubmed-meshheading:2578432-T-Lymphocytes, Regulatory,
pubmed-meshheading:2578432-Ultraviolet Rays
|
|
pubmed:year |
1985
|
|
pubmed:articleTitle |
Suppression of lymphoproliferation by hapten-specific suppressor T lymphocytes from mice exposed to ultraviolet radiation.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
