|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1985-3-14
|
|
pubmed:abstractText |
T3 is a human differentiation antigen expressed exclusively on mature T cells. In this study it is shown that anti-T3 monoclonal antibodies, in addition to their capacity to induce T cells to proliferate, are able to induce antigen-specific cytotoxic T lymphocyte clones to mediate antigen nonspecific cytotoxic activity. It is furthermore shown that anti-T3 reagents are able to trigger lytic activity in T cell clones characterized as noncytotoxic antigen-specific proliferating T cells. The data presented indicate that perturbation of T3 can trigger the lytic machinery in cytolytic as well as noncytolytic T cell clones.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0014-2980
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
15
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
88-91
|
|
pubmed:dateRevised |
2004-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:2578402-Antibodies, Monoclonal,
pubmed-meshheading:2578402-Antigen-Antibody Reactions,
pubmed-meshheading:2578402-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:2578402-Antigens, Surface,
pubmed-meshheading:2578402-Clone Cells,
pubmed-meshheading:2578402-Cytotoxicity, Immunologic,
pubmed-meshheading:2578402-Epitopes,
pubmed-meshheading:2578402-Humans,
pubmed-meshheading:2578402-Lymphocyte Activation,
pubmed-meshheading:2578402-Lymphocyte Function-Associated Antigen-1,
pubmed-meshheading:2578402-T-Lymphocytes, Cytotoxic
|
|
pubmed:year |
1985
|
|
pubmed:articleTitle |
Antigen-specific cytotoxic T cell and antigen-specific proliferating T cell clones can be induced to cytolytic activity by monoclonal antibodies against T3.
|
|
pubmed:publicationType |
Journal Article
|
