Linked Life Data

2576818

Source:http://linkedlifedata.com/resource/pubmed/id/2576818

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1990-6-6
pubmed:abstractText
The phenomenon of "learned helplessness" is characterized by elements of motor, cognitive and emotional deficit, and it is particularly suitable to be used as a "model" of behavioural depression. There is no doubt about the central role of the cerebral noradrenaline and serotonin in the stress-induced behavioural deficit. The effects of two known beta-adrenoceptor agonists--salbutamol and trimetoquinol--and the beta-adrenergic blockers propranolol and compound 3B, with beta-blocking activity equipotent to that of propranolol, were investigated under conditions of "prophylactic" and "therapeutic" administration in rats subjected to stress by modelling of the behaviour of learned helplessness. Among the serotoninergic agents, the effects of 5-hydroxytryptophane and of the inhibitor of serotonin synthesis, parachlorophenylalanine, were studied. The experimental results show a favourable effect on the behavioural deficit, caused by the blocking of the adrenergic transmitter system and by increasing the activity of the serotoninergic system.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0323-9950
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
17-24
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Effect of beta-adrenergic and serotoninergic agents on the stress-induced behaviour of "learned helplessness" in rats.
pubmed:affiliation
Research Institute of Pharmacology and Pharmacy, Medical Academy, Sofia.
pubmed:publicationType
Journal Article