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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1990-2-13
|
| pubmed:abstractText |
Because T-cell dysfunctions have been reported in patients with primary Sjögren's syndrome (SS), peripheral blood mononuclear cell (PBMC) proliferation obtained with anti-CD3 and anti-CD2 monoclonal antibodies was evaluated in these patients. Anti-CD3-induced mitogenesis, which varied widely among the patients, was lower in subjects with evidence of anti-SSA and anti-SSB antibodies than in controls. Moreover, the anti-CD2-induced response was depressed in about half the patients and the nonresponders were mainly those with anti-SSA and anti-SSB antibodies. Phorbol myristate acetate, a protein kinase C activator, used alone or added to anti-CD3, induced greater proliferation in patients than in control PBMC. In contrast, exogenous recombinant interleukin 2 (rIL-2) did not significantly enhance the anti-CD2-induced response of patients' PBMC, as it did in normal PBMC. Peripheral blood and parotid T cells from a patient with well-defined primary SS and parotid enlargement also responded poorly to anti-CD2 stimulation. Exogenous rIL-2 restored T-cell proliferation only in the salivary gland cultures of this patient. The present findings suggest that there is a T-cell activation defect in subjects with primary SS, particularly in those with circulating anti-SSA and anti-SSB antibodies. In addition, the difference in the response to IL-2 of peripheral blood and parotid-infiltrating T cells would seem to indicate that T-cell subsets are differently distributed in the blood and inflammation site.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Antinuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD2,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/SS-A antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/SS-B antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0392-856X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
7 Suppl 3
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
S129-34
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:2575023-Adult,
pubmed-meshheading:2575023-Antibodies, Antinuclear,
pubmed-meshheading:2575023-Antibodies, Monoclonal,
pubmed-meshheading:2575023-Antigens, CD2,
pubmed-meshheading:2575023-Antigens, CD3,
pubmed-meshheading:2575023-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:2575023-Female,
pubmed-meshheading:2575023-Humans,
pubmed-meshheading:2575023-Interleukin-2,
pubmed-meshheading:2575023-Lymphocyte Activation,
pubmed-meshheading:2575023-Male,
pubmed-meshheading:2575023-Middle Aged,
pubmed-meshheading:2575023-Receptors, Antigen, T-Cell,
pubmed-meshheading:2575023-Receptors, Immunologic,
pubmed-meshheading:2575023-Sjogren's Syndrome,
pubmed-meshheading:2575023-T-Lymphocytes,
pubmed-meshheading:2575023-Tetradecanoylphorbol Acetate
|
| pubmed:articleTitle |
Anti-CD3 and anti-CD2-induced T-cell activation in primary Sjögren's syndrome.
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| pubmed:affiliation |
Department of Internal Medicine, University of Perugia, Italy.
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| pubmed:publicationType |
Journal Article
|