Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8676
|
| pubmed:dateCreated |
1990-1-17
|
| pubmed:abstractText |
In a prospective study of pregnant women infected with human immunodeficiency virus type 1 (HIV-1) in Brooklyn, New York, USA, 16 (29%) of 55 evaluable infants were infected with HIV-1. 9 infants had paediatric acquired immunodeficiency syndrome, 6 had less severe clinical manifestations of HIV-1 infection, and 1 was symptom-free but was seropositive for HIV-1 beyond 15 months of age. The 10 infants born at 37 weeks of gestation or earlier were at higher risk of HIV-1 infection than infants born at 38 weeks of gestation or later (60% vs 22%) but the median age at appearance of disease was approximately 5 months in both groups. The HIV-1 transmission rate was not associated with predelivery levels of maternal T cells, anti-p24, or neutralising antibodies but it was higher, among full-term infants, for those with mothers in the lowest third of the distribution of anti-gp120 levels (53%). On immunoblot, transmitting mothers lacked a gp120 band but not other bands. Protection was not associated with antibody to recombinant peptides from the hypervariable region of the major neutralising gp120 epitope, and the anti-gp120 endpoint dilution titre was similar in transmitting and non-transmitting mothers. Mothers of uninfected full-term infants appear to confer immunological protection against HIV-1 infection of their offspring by way of a high-affinity antibody to a gp120 epitope, whose specificity has importance for vaccine development and possibly perinatal immunotherapy.
|
| pubmed:grant | |
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, gag,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Core Protein p24,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Envelope Protein gp120,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Core Proteins
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0140-6736
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
9
|
| pubmed:volume |
2
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
N
|
| pubmed:pagination |
1351-4
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2574302-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:2574302-Blotting, Western,
pubmed-meshheading:2574302-Female,
pubmed-meshheading:2574302-Gene Products, gag,
pubmed-meshheading:2574302-Gestational Age,
pubmed-meshheading:2574302-HIV Antibodies,
pubmed-meshheading:2574302-HIV Core Protein p24,
pubmed-meshheading:2574302-HIV Envelope Protein gp120,
pubmed-meshheading:2574302-HIV-1,
pubmed-meshheading:2574302-Humans,
pubmed-meshheading:2574302-Immunoenzyme Techniques,
pubmed-meshheading:2574302-Infant, Newborn,
pubmed-meshheading:2574302-Infant, Premature, Diseases,
pubmed-meshheading:2574302-Pregnancy,
pubmed-meshheading:2574302-Pregnancy Complications, Infectious,
pubmed-meshheading:2574302-Prospective Studies,
pubmed-meshheading:2574302-Radioimmunoassay,
pubmed-meshheading:2574302-Risk Factors,
pubmed-meshheading:2574302-Viral Core Proteins
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Mother-to-infant transmission of human immunodeficiency virus type 1: association with prematurity or low anti-gp120.
|
| pubmed:affiliation |
Viral Epidemiology Section, National Cancer Institute, Bethesda, Maryland.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|