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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1990-1-25
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pubmed:abstractText |
We have used several DNA probes which simultaneously recognize multiple loci to follow the segregation of a large number of minisatellite loci through two large reference pedigrees. The segregation data were analyzed for linkage to previously characterized marker loci using RFLP mapping data for these pedigrees from a previous study and from the Centre d'Etude du Polymorphisme Humain data bank. In this way we have mapped 31 separate minisatellite alleles of a total of 146 studied. The results of these analyses suggest that the distribution of minisatellites in the human genome is skewed toward telomeres and is highly clustered in character. A group of at least five separate minisatellites was found at 7 qter, and smaller clusters are present in several other regions. We detected a smaller than expected number of linkages, perhaps because of the clustering of minisatellite loci. The 7qter minisatellite cluster is in a region of excess male meiotic recombination, and in this respect is similar to minisatellite clusters at 16pter and in the X-Y pseudoautosomal region.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
|
pubmed:issn |
0888-7543
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
761-72
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:2574144-Alleles,
pubmed-meshheading:2574144-Blotting, Southern,
pubmed-meshheading:2574144-DNA, Satellite,
pubmed-meshheading:2574144-DNA Probes,
pubmed-meshheading:2574144-Female,
pubmed-meshheading:2574144-Genetic Linkage,
pubmed-meshheading:2574144-Humans,
pubmed-meshheading:2574144-Lod Score,
pubmed-meshheading:2574144-Male,
pubmed-meshheading:2574144-Nucleotide Mapping,
pubmed-meshheading:2574144-Pedigree,
pubmed-meshheading:2574144-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:2574144-Recombination, Genetic
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pubmed:year |
1989
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pubmed:articleTitle |
Simultaneous genetic mapping of multiple human minisatellite sequences using DNA fingerprinting.
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pubmed:affiliation |
MRC Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Headington, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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