Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
1990-1-24
pubmed:abstractText
Spatially regulated expression of the homeotic gene Ultrabithorax (Ubx) in the visceral mesoderm can be mimicked in transformed Drosophila embryos by expression of a Ubx--beta-galactosidase fusion gene. Here we show that a proximal homeoprotien binding sequence downstream of the Ubx transcription start site, the B element, is required for this pattern. A distal upstream Ubx sequence, but not the B element, is sufficient to confer the pattern if linked to an hsp70 TATA box in a heterologous construct. The pattern in this case requires Ubx function, like endogenous Ubx expression in the visceral mesoderm, suggesting that the distal upstream sequence contains an important target sequence for autoregulation. We propose that the B element, in the context of the Ubx promoter, functions to mediate enhancer function of the distal sequence. Thus, the visceral mesoderm pattern requires coordinate action of a proximal and a distal regulatory element.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-103000, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-14650432, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-16453691, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-16453777, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-2493136, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-2502714, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-2563673, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-2567632, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-2567637, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-2569362, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-2887293, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-2895896, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-2897241, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-2897243, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-2897631, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-2902927, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-2902928, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-2904653, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-2904654, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-2904655, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-2904838, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-2905023, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-2905684, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-2911348, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-2961459, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-3025588, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-3046753, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-3050531, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-3085957, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-3128460, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-3131017, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-3265124, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-4079979, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-6313220, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-6323992, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-6330566, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-6429549, http://linkedlifedata.com/resource/pubmed/commentcorrection/2574106-6776413
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0261-4189
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4143-51
pubmed:dateRevised
2010-9-9
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Coordinate action of a proximal homeoprotein binding site and a distal sequence confers the Ultrabithorax expression pattern in the visceral mesoderm.
pubmed:affiliation
Zoological Institute, University of Zürich, Switzerland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't