Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:2573952rdf:typepubmed:Citationlld:pubmed
pubmed-article:2573952lifeskim:mentionsumls-concept:C0006675lld:lifeskim
pubmed-article:2573952lifeskim:mentionsumls-concept:C0013080lld:lifeskim
pubmed-article:2573952lifeskim:mentionsumls-concept:C0022022lld:lifeskim
pubmed-article:2573952lifeskim:mentionsumls-concept:C1704632lld:lifeskim
pubmed-article:2573952lifeskim:mentionsumls-concept:C0871261lld:lifeskim
pubmed-article:2573952lifeskim:mentionsumls-concept:C2911692lld:lifeskim
pubmed-article:2573952lifeskim:mentionsumls-concept:C1706817lld:lifeskim
pubmed-article:2573952lifeskim:mentionsumls-concept:C0031586lld:lifeskim
pubmed-article:2573952lifeskim:mentionsumls-concept:C0048451lld:lifeskim
pubmed-article:2573952lifeskim:mentionsumls-concept:C0878412lld:lifeskim
pubmed-article:2573952pubmed:issue5lld:pubmed
pubmed-article:2573952pubmed:dateCreated1989-12-26lld:pubmed
pubmed-article:2573952pubmed:abstractTextThe proliferative response of purified T cells to anti-CD2 monoclonal antibodies (T112 plus T113) was found to be markedly reduced in 12 subjects with Down's syndrome (DS). The addition of phorbol ester PMA, which activates Ca2+/phospholipid-dependent enzyme protein kinase C, or calcium ionophore A23187, which increases intracytosolic free Ca2+ concentration, enhanced, but did not normalize, the defective anti-CD2-mediated T-cell mitogenesis. In contrast, the proliferation of resting lymphocytes from trisomic patients was comparable to that of the control cells when PMA and A23187 were used as co-blastogenic reagents. Because PMA and A23187 together bypass the early activation pathways and promote T-cell growth through the direct induction of membrane interleukin 2 (IL-2) receptor expression and IL-2 synthesis and secretion, it could reasonably be hypothesized that the faulty DS T-cell activation induced by antigen or mitogen is due to a deranged transmembrane signal transduction, rather than a defect in the later intracellular events.lld:pubmed
pubmed-article:2573952pubmed:languageenglld:pubmed
pubmed-article:2573952pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2573952pubmed:citationSubsetIMlld:pubmed
pubmed-article:2573952pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2573952pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2573952pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2573952pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2573952pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:2573952pubmed:statusMEDLINElld:pubmed
pubmed-article:2573952pubmed:monthNovlld:pubmed
pubmed-article:2573952pubmed:issn0300-9475lld:pubmed
pubmed-article:2573952pubmed:authorpubmed-author:ArcangeliCClld:pubmed
pubmed-article:2573952pubmed:authorpubmed-author:VaccaroRRlld:pubmed
pubmed-article:2573952pubmed:authorpubmed-author:BertottoAAlld:pubmed
pubmed-article:2573952pubmed:authorpubmed-author:CrupiSSlld:pubmed
pubmed-article:2573952pubmed:authorpubmed-author:GerliRRlld:pubmed
pubmed-article:2573952pubmed:authorpubmed-author:BIGINNlld:pubmed
pubmed-article:2573952pubmed:authorpubmed-author:ScalisiBBlld:pubmed
pubmed-article:2573952pubmed:authorpubmed-author:FabiettiGGlld:pubmed
pubmed-article:2573952pubmed:issnTypePrintlld:pubmed
pubmed-article:2573952pubmed:volume30lld:pubmed
pubmed-article:2573952pubmed:ownerNLMlld:pubmed
pubmed-article:2573952pubmed:authorsCompleteYlld:pubmed
pubmed-article:2573952pubmed:pagination583-6lld:pubmed
pubmed-article:2573952pubmed:dateRevised2004-11-17lld:pubmed
pubmed-article:2573952pubmed:meshHeadingpubmed-meshheading:2573952-...lld:pubmed
pubmed-article:2573952pubmed:meshHeadingpubmed-meshheading:2573952-...lld:pubmed
pubmed-article:2573952pubmed:meshHeadingpubmed-meshheading:2573952-...lld:pubmed
pubmed-article:2573952pubmed:meshHeadingpubmed-meshheading:2573952-...lld:pubmed
pubmed-article:2573952pubmed:meshHeadingpubmed-meshheading:2573952-...lld:pubmed
pubmed-article:2573952pubmed:meshHeadingpubmed-meshheading:2573952-...lld:pubmed
pubmed-article:2573952pubmed:meshHeadingpubmed-meshheading:2573952-...lld:pubmed
pubmed-article:2573952pubmed:meshHeadingpubmed-meshheading:2573952-...lld:pubmed
pubmed-article:2573952pubmed:meshHeadingpubmed-meshheading:2573952-...lld:pubmed
pubmed-article:2573952pubmed:meshHeadingpubmed-meshheading:2573952-...lld:pubmed
pubmed-article:2573952pubmed:meshHeadingpubmed-meshheading:2573952-...lld:pubmed
pubmed-article:2573952pubmed:meshHeadingpubmed-meshheading:2573952-...lld:pubmed
pubmed-article:2573952pubmed:meshHeadingpubmed-meshheading:2573952-...lld:pubmed
pubmed-article:2573952pubmed:year1989lld:pubmed
pubmed-article:2573952pubmed:articleTitleT-cell response to phorbol ester PMA and calcium ionophore A23187 in Down's syndrome.lld:pubmed
pubmed-article:2573952pubmed:affiliationDepartment of Paediatrics, Perugia University Medical School, Italy.lld:pubmed
pubmed-article:2573952pubmed:publicationTypeJournal Articlelld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:2573952lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:2573952lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:2573952lld:pubmed