Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
21
pubmed:dateCreated
1989-12-27
pubmed:databankReference
pubmed:abstractText
The genes encoding procyclin, the major glycoprotein expressed on the surface of procyclic forms of Trypanosoma brucei, comprise a multigene family. It has previously been demonstrated that procyclin genes in cloned trypanosome strains from Kenya and Uganda show restriction fragment polymorphisms. A detailed study of the Kenyan strain 227 has revealed that procyclin genes are arranged in tandem at 3 distinct loci (Pro A, B and C) and that the polymorphism is due to the duplication of 1.3 kb in the Pro A locus, which has generated an additional procyclin gene. Northern blot analysis has shown that at least 2 loci are transcribed and that a minimum of 3 procyclin genes are expressed within a cloned line. The transcription of procyclin genes is resistant to 1 mg ml-1 alpha-amanitin, whereas that of the 5' flanking gene in the Pro A locus is sensitive. This observation suggests that the two genes form part of separate transcription units with a promoter between them.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-2464763, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-2645304, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-2651916, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-271968, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-2720787, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-2725502, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-2827116, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-2886912, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-2888112, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-2893975, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-292111, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-2985470, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-3067793, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-3071245, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-3185541, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-3194021, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-3221866, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-3280138, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-3308454, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-3370673, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-3380094, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-3393912, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-3512712, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-3658696, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-3670296, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-3724860, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-3808022, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-3928017, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-4571084, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-4761771, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-6096214, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-6163126, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-6163590, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-6272213, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-6278436, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-6593722, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-7121578, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-7121582, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-7278981, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-7422004, http://linkedlifedata.com/resource/pubmed/commentcorrection/2573878-881736
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0305-1048
pubmed:author
pubmed:issnType
Print
pubmed:day
11
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
8727-39
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:2573878-Amanitins, pubmed-meshheading:2573878-Amino Acid Sequence, pubmed-meshheading:2573878-Animals, pubmed-meshheading:2573878-Base Sequence, pubmed-meshheading:2573878-Blotting, Northern, pubmed-meshheading:2573878-Blotting, Southern, pubmed-meshheading:2573878-Electrophoresis, Agar Gel, pubmed-meshheading:2573878-Membrane Glycoproteins, pubmed-meshheading:2573878-Molecular Sequence Data, pubmed-meshheading:2573878-Nucleic Acid Heteroduplexes, pubmed-meshheading:2573878-Nucleic Acid Hybridization, pubmed-meshheading:2573878-Polymorphism, Restriction Fragment Length, pubmed-meshheading:2573878-Protozoan Proteins, pubmed-meshheading:2573878-RNA, Messenger, pubmed-meshheading:2573878-Restriction Mapping, pubmed-meshheading:2573878-Transcription, Genetic, pubmed-meshheading:2573878-Trypanosoma brucei brucei, pubmed-meshheading:2573878-Variant Surface Glycoproteins, Trypanosoma
pubmed:year
1989
pubmed:articleTitle
Duplication and transcription of procyclin genes in Trypanosoma brucei.
pubmed:affiliation
Kernforschungszentrum Karlsruhe, Institut für Genetik und Toxikologie, Karlsruhe, FRG.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't