Linked Life Data

2572856

Source:http://linkedlifedata.com/resource/pubmed/id/2572856

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8672
pubmed:dateCreated
1989-12-18
pubmed:abstractText
When activated under physiological or pathological conditions leucocytes transiently adhere to one another or to other cell types such as vascular endothelial cells. This adhesiveness is mediated by specific cell adhesion molecules (CAMs). There are two molecular pathways of leucocyte adhesion--the binding of CD11a-c/CD18 (Leu-CAM family) on leucocytes to CD54 (ICAM-1) on mononuclear leucocytes, fibroblasts, and epithelial and vascular endothelial cells, or of CD2 on T cells to CD58, a cell surface molecule found on a broad range of tissue cells. The adhesion process is essential for leucocyte-mediated cytotoxicity, phagocytosis, chemotaxis, and induction of lymphocyte proliferation and differentiation. It also participates in homing of lymphocytes into lymphoid organs and leucocyte migration from the vascular compartment to extravascular tissues. Leucocyte adhesion is thus a critical step in the development of immune and inflammatory responses. An inherited deficiency of the Leu-CAM family leads to recurrent bacterial infections, which can be fatal in early life, and lack of CAMs on Burkitt's lymphoma cells may enable these cells to escape immunesurveillance.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0140-6736
pubmed:author
pubmed:issnType
Print
pubmed:day
11
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1139-42
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Leucocyte adhesion to cells in immune and inflammatory responses.
pubmed:affiliation
Department of Immunology, Karolinska Institutet, Stockholm, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't