|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
8670
|
|
pubmed:dateCreated |
1989-12-5
|
|
pubmed:abstractText |
NG monomethyl-L-arginine (L-NMMA), a specific inhibitor of the synthesis of endothelium-derived nitric oxide (NO), was infused into the brachial arteries of healthy volunteers to study the role of NO in the control of forearm blood flow. L-NMMA caused a 50% fall in basal blood flow and attenuated the dilator response to infused acetylcholine but not that to glyceryl trinitrate. These results indicate that the dilator action of endothelium-derived NO contributes to the control of basal and stimulated regional blood flow in man. Impairment of production of NO might account for the abnormalities in vascular reactivity that characterise a wide variety of disease states.
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0140-6736
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
28
|
|
pubmed:volume |
2
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
997-1000
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:2572793-Acetylcholine,
pubmed-meshheading:2572793-Adult,
pubmed-meshheading:2572793-Arginine,
pubmed-meshheading:2572793-Brachial Artery,
pubmed-meshheading:2572793-Dose-Response Relationship, Drug,
pubmed-meshheading:2572793-Drug Evaluation,
pubmed-meshheading:2572793-Endothelium, Vascular,
pubmed-meshheading:2572793-Female,
pubmed-meshheading:2572793-Forearm,
pubmed-meshheading:2572793-Humans,
pubmed-meshheading:2572793-Infusions, Intra-Arterial,
pubmed-meshheading:2572793-Male,
pubmed-meshheading:2572793-Muscle Tonus,
pubmed-meshheading:2572793-Nitric Oxide,
pubmed-meshheading:2572793-Nitroglycerin,
pubmed-meshheading:2572793-Regional Blood Flow,
pubmed-meshheading:2572793-Time Factors,
pubmed-meshheading:2572793-Vasodilation,
pubmed-meshheading:2572793-omega-N-Methylarginine
|
|
pubmed:year |
1989
|
|
pubmed:articleTitle |
Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man.
|
|
pubmed:affiliation |
Department of Pharmacology and Clinical Pharmacology, St George's Hospital Medical School, London.
|
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Controlled Clinical Trial,
Research Support, Non-U.S. Gov't
|
