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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1989-12-1
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pubmed:abstractText |
Decreased responses to antigens and lectins are a characteristic feature of peripheral blood lymphocytes isolated from patients with the acquired immunodeficiency syndrome (AIDS). The in vitro addition of recombinant gamma interferon (IFN-gamma) to cultures of peripheral blood lymphocytes obtained from patients with AIDS resulted in an augmented proliferative response [( 3H]thymidine uptake) to phytohemagglutinin (PHA) and an enrichment in CD4+ and CD8+ T lymphocytes. In AIDS cultures stimulated with PHA, IFN-gamma increased the release of T-cell growth factors and enhanced the expression of interleukin-2 receptors on activated lymphocytes. Responsiveness to PHA was augmented, albeit to a lesser extent, by IFN-gamma in cultures derived from normal donors. Proliferation to microbial antigens including herpes simplex virus, cytomegalo virus, and Candida albicans was increased by IFN-gamma in cultures established from a group of AIDS patients with Kaposi's sarcoma who had no history of opportunistic infection.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2572558-2430298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2572558-2857946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2572558-2863475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2572558-2903953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2572558-2903954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2572558-3005400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2572558-3018647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2572558-3047875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2572558-3090545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2572558-3096401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2572558-3122616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2572558-3129509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2572558-3157753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2572558-3277274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2572558-3838854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2572558-3918107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2572558-6182091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2572558-6200566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2572558-6200937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2572558-6232458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2572558-6235286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2572558-6296263,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2572558-6330202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2572558-6403609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2572558-6418799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2572558-6422299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2572558-6429537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2572558-6436036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2572558-6438249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2572558-6439741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2572558-6606643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2572558-6712031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2572558-6835320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2572558-7028425
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3619-28
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:2572558-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:2572558-Antigens, Bacterial,
pubmed-meshheading:2572558-Antigens, CD8,
pubmed-meshheading:2572558-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:2572558-CD4-Positive T-Lymphocytes,
pubmed-meshheading:2572558-Cells, Cultured,
pubmed-meshheading:2572558-Humans,
pubmed-meshheading:2572558-Interferon Type I,
pubmed-meshheading:2572558-Interferon-gamma,
pubmed-meshheading:2572558-Lectins,
pubmed-meshheading:2572558-Lymphocyte Activation,
pubmed-meshheading:2572558-Lymphocytes,
pubmed-meshheading:2572558-Lymphokines,
pubmed-meshheading:2572558-Receptors, Interleukin-2,
pubmed-meshheading:2572558-Recombinant Proteins,
pubmed-meshheading:2572558-Sarcoma, Kaposi,
pubmed-meshheading:2572558-Statistics as Topic
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pubmed:year |
1989
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pubmed:articleTitle |
Recombinant human gamma interferon enhances in vitro activation of lymphocytes isolated from patients with acquired immunodeficiency syndrome.
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pubmed:affiliation |
Laboratory of Infectious Diseases, Dana-Farber Cancer Institute, Boston, Massachusetts 02115.
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