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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1989-12-19
|
| pubmed:abstractText |
1. Selected lace bug-derived and related compounds were shown to be in vitro inhibitors of mammalian and insect derived prostaglandin H synthase. 2. Two compounds, 2,6-dihydroxyacetophenone and 2,4,6-trihydroxyacetophenone, were significantly better inhibitors of prostaglandin synthesis than aspirin, whereas 2-nonyl-5,7-dihydroxychromone and 1-(2,6-dihydroxyphenyl) dodecan-1-one were equivalent to aspirin. 3. 2,4-Dihydroxyacetophenone was less effective in inhibiting the prostaglandin H synthase and 2-nonyl-5-hydroxychromanone showed no inhibition. 4. Three compounds, 2,6-dihydroxyacetophenone, 2,4,6-trihydroxyacetophenone and 1-(2,6-dihydroxyphenyl) dodecan-1-one were equal to aspirin in PSI inhibition with fat body preparations of the American cockroach Periplaneta americana L.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0742-8413
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
93
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
253-5
|
| pubmed:dateRevised |
2007-7-23
|
| pubmed:meshHeading | |
| pubmed:year |
1989
|
| pubmed:articleTitle |
In vitro inhibition of prostaglandin H synthase by compounds from the exocrine secretions of lace bugs.
|
| pubmed:affiliation |
Department of Biochemistry, University of Nevada-Reno 89557-0014.
|
| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|