Linked Life Data

2571260

Source:http://linkedlifedata.com/resource/pubmed/id/2571260

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1989-10-19
pubmed:abstractText
The medetomidine/ketamine combination was evaluated as an anaesthetic in cats undergoing ovariectomy. It was compared with acepromazine/ketamine, xylazine/ketamine and zolazepam/tiletamine combinations. 60 animals, divided into 6 groups of 10 animals were involved. Medetomidine highly potentiated the anaesthetic effects of ketamine and balanced the two main disadvantages of this drug: weak muscle relaxation and poor analgesia in deep organs. 80 micrograms medetomidine/kg--5 mg ketamine/kg provided a duration of anaesthesia longer than 1 mg acepromazine/kg--10 mg ketamine/kg, and not significantly different from those induced by 1 mg xylazine/kg--10 mg ketamine/kg or 7.5 mg zolazepam/kg--7.5 mg tiletamine/kg. Furthermore, it produced a better muscle relaxation than acepromazine/ketamine and zolazepam/tiletamine combinations. The analgesia in deep organs observed after medetomidine/ketamine administration appeared to be more substantial than that observed after acepromazine/ketamine or xylazine/ketamine combinations. The stimulating effect on heart rate of ketamine compensated the bradycardiac effect of medetomidine. Nevertheless, the administration of 80 micrograms medetomidine/kg--5 mg ketamine/kg resulted as with xylazine/ketamine, in decreasing heart rate whereas acepromazine/ketamine and zolazepam/tiletamine combinations did not exhibit bradycardiac effect. It was concluded that the medetomidine/ketamine combination provided a suitable anaesthesia for cats characterized by rapid induction, good muscle relaxation, good analgesia and bradycardia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0065-1699
pubmed:author
pubmed:issnType
Print
pubmed:volume
85
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
117-23
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Medetomidine/ketamine anaesthesia in cats.
pubmed:publicationType
Journal Article, Comparative Study