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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1989-10-18
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pubmed:databankReference |
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pubmed:abstractText |
The t complex of the mouse has an important role in male germ cell development and function. Multiple mutations in the t complex interact to alter profoundly the transmission ratio of t complex-bearing sperm or to cause complete sterility or semisterility. We have isolated a multigene family, tctex-1, by screening a testicular cell cDNA library with two reciprocally subtracted testicular cDNA probes. The tctex-1 gene family produces an abundant, virtually germ cell-specific transcript that is 8-fold overexpressed in t homozygotes. The aberrant expression of tctex-1 is solely dependent on the t haplotype genes and occurs only in germ cells. The chromosomal location and pattern of expression of tctex-1 make it a candidate for involvement in male sterility.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
969-79
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2570638-Amino Acid Sequence,
pubmed-meshheading:2570638-Animals,
pubmed-meshheading:2570638-Base Sequence,
pubmed-meshheading:2570638-Chromosome Mapping,
pubmed-meshheading:2570638-Cloning, Molecular,
pubmed-meshheading:2570638-DNA,
pubmed-meshheading:2570638-Female,
pubmed-meshheading:2570638-Gene Expression Regulation,
pubmed-meshheading:2570638-Genes,
pubmed-meshheading:2570638-Infertility, Male,
pubmed-meshheading:2570638-Male,
pubmed-meshheading:2570638-Mice,
pubmed-meshheading:2570638-Molecular Sequence Data,
pubmed-meshheading:2570638-Multigene Family,
pubmed-meshheading:2570638-Nucleic Acid Hybridization,
pubmed-meshheading:2570638-Ovary,
pubmed-meshheading:2570638-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:2570638-Testis
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pubmed:year |
1989
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pubmed:articleTitle |
tctex-1: a candidate gene family for a mouse t complex sterility locus.
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pubmed:affiliation |
Department of Zoology, University of Texas, Austin 78712.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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