Linked Life Data

2570566

Source:http://linkedlifedata.com/resource/pubmed/id/2570566

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
1989-9-28
pubmed:abstractText
A full-length cDNA clone, pmSAP3, encoding, the serum P component (SAP), has been used to search for DNA fragment length variation among mouse strains previously analyzed for differences in endogenous SAP levels. Three alleles were found using EcoRI-digested DNA. The finding of a single 5.4-kb fragment, allele d, in DNA from DBA/2J mice suggests the presence of a single Sap locus. Segregation of DNA fragment associated with Sapb and Sapd alleles was analyzed in three sets of recombinant inbred (RI) strains. The strain distribution pattern found for the Sap alleles was identical to that of alleles of Ly-9 in 43 individual RI strains, suggesting tight linkage with Ly-9 on mouse chromosome 1. In the BXD RI strains, the SDP of the Sap locus, defined by the difference in the endogenous SAP level, is also identical to the SDP of the DNA fragments. We propose to redesignate the Sap locus to include both the structural element defined by the DNA polymorphism and the regulatory element involved in the regulation of SAP synthesis. The Sap locus is the major genetic element contributing to the regulation of SAP production. Other genetic factors are also involved, as shown by the presence of nonparental phenotypes in the individual BXH RI strains.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0006-2928
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
229-37
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Chromosomal location of the gene encoding the murine acute-phase protein serum amyloid P-component (SAP).
pubmed:affiliation
Department of Pathology, Tokyo Metropolitan Institute of Gerontology, Japan.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't