| pubmed-article:2570549 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2570549 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:2570549 | lifeskim:mentions | umls-concept:C0023884 | lld:lifeskim |
| pubmed-article:2570549 | lifeskim:mentions | umls-concept:C0011710 | lld:lifeskim |
| pubmed-article:2570549 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:2570549 | lifeskim:mentions | umls-concept:C0314603 | lld:lifeskim |
| pubmed-article:2570549 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:2570549 | lifeskim:mentions | umls-concept:C1979928 | lld:lifeskim |
| pubmed-article:2570549 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:2570549 | lifeskim:mentions | umls-concept:C1880177 | lld:lifeskim |
| pubmed-article:2570549 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2570549 | pubmed:dateCreated | 1989-10-3 | lld:pubmed |
| pubmed-article:2570549 | pubmed:abstractText | Outbred New Zealand white rabbits exhibit two phenotypes, 21H and 21L, corresponding to rates greater than or less than 1 nmol/min/mg, respectively, for liver microsomal progesterone 21-hydroxylase activity. In contrast, the inbred strain III/J exhibits only the 21L phenotype. Two 21H male New Zealand white rabbits were mated with several female III/J rabbits to produce a total 46 progeny. Both the 21H and 21L phenotypes were evident among male and female offspring in roughly equal numbers. Backcrosses between 21L progeny and III/J rabbits exhibit only the 21L phenotype, whereas 21H offspring yield both 21H and 21L progeny when backcrossed to the 21L inbred strain III/J. These results are consistent with autosomal dominant inheritance of the 21H phenotype. Analysis of Southern blots of genomic DNA digested with the restriction endonuclease KpnI reveals 20-, 13-, and 9-kb fragments that hybridize with a probe derived from the 3'-untranslated region of the 21-hydroxylase cDNA. The 13-kb band is not observed for strain III/J or 21L progeny of strain III/J crossed with 21H rabbits, but it is detected for both 21H fathers and 21H progeny indicating that the genetically determined difference of 21-hydroxylase expression is inherited cis to the gene for P450IIC5, the hepatic progesterone 21-hydroxylase. Electrophoretic analysis of P450IIC5 synthesized in vitro from mRNA isolated from 21L and 21H rabbits reveals that little or no P450IIC5 is synthesized from 21L mRNAs. A second immunoreactive, electrophoretically distinct protein is synthesized from both 21L and 21H mRNAs to a similar extent but in lesser amounts than P450IIC5. The second protein could represent either an allozymic form of the enzyme or the product of a distinct locus. Thus, it is likely that distinct structural genes for P450IIC5 contribute to the differences in P450-mediated metabolism in 21L as compared to 21H rabbits. | lld:pubmed |
| pubmed-article:2570549 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2570549 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2570549 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2570549 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2570549 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2570549 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2570549 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2570549 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2570549 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2570549 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2570549 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2570549 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2570549 | pubmed:issn | 0003-9861 | lld:pubmed |
| pubmed-article:2570549 | pubmed:author | pubmed-author:TukeyR HRH | lld:pubmed |
| pubmed-article:2570549 | pubmed:author | pubmed-author:JohnsonE FEF | lld:pubmed |
| pubmed-article:2570549 | pubmed:author | pubmed-author:FinlaysonMM | lld:pubmed |
| pubmed-article:2570549 | pubmed:author | pubmed-author:PendurthiU... | lld:pubmed |
| pubmed-article:2570549 | pubmed:author | pubmed-author:HujsakC MCM | lld:pubmed |
| pubmed-article:2570549 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2570549 | pubmed:volume | 273 | lld:pubmed |
| pubmed-article:2570549 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2570549 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2570549 | pubmed:pagination | 273-80 | lld:pubmed |
| pubmed-article:2570549 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2570549 | pubmed:meshHeading | pubmed-meshheading:2570549-... | lld:pubmed |
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| pubmed-article:2570549 | pubmed:meshHeading | pubmed-meshheading:2570549-... | lld:pubmed |
| pubmed-article:2570549 | pubmed:meshHeading | pubmed-meshheading:2570549-... | lld:pubmed |
| pubmed-article:2570549 | pubmed:meshHeading | pubmed-meshheading:2570549-... | lld:pubmed |
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| pubmed-article:2570549 | pubmed:meshHeading | pubmed-meshheading:2570549-... | lld:pubmed |
| pubmed-article:2570549 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2570549 | pubmed:articleTitle | Genetic contributions to the variation among rabbits of liver microsomal deoxycorticosterone synthesis. | lld:pubmed |
| pubmed-article:2570549 | pubmed:affiliation | Department of Basic and Clinical Research, Research Institute of Scripps Clinic, La Jolla, California 92037. | lld:pubmed |
| pubmed-article:2570549 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2570549 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2570549 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2570549 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2570549 | lld:pubmed |
