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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1989-9-29
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pubmed:abstractText |
Restriction fragment length variants have been exploited to map genetically Rb-1, the murine homolog of the human retinoblastoma gene. Rb-1 localized to mouse chromosome 14 on the basis of results from analysis of somatic cell hybrids. In an interspecific backcross involving Mus spretus, Rb-1 and the murine homolog of the human esterase D gene (ESD), which we refer to here as Esd, were inseparable. Furthermore, the strain distribution patterns of Rb-1 and Es-10 are the same in 31 of 32 recombinant inbred strains. Close linkage of the chromosome 14 morphological marker hairless (hr) to Rb-1 is also implied. These results localize Rb-1 on the mouse linkage map and provide close genetic markers to follow Rb-1 in somatic as well as in germline genetic experiments. Additionally, the results suggest that Es-10 is the murine homolog of ESD and provide further evidence for linkage conservation during mammalian evolution.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0888-7543
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
70-5
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:2570031-Animals,
pubmed-meshheading:2570031-Biological Evolution,
pubmed-meshheading:2570031-Carboxylesterase,
pubmed-meshheading:2570031-Carboxylic Ester Hydrolases,
pubmed-meshheading:2570031-Chromosome Mapping,
pubmed-meshheading:2570031-Cricetinae,
pubmed-meshheading:2570031-Crosses, Genetic,
pubmed-meshheading:2570031-DNA Probes,
pubmed-meshheading:2570031-Disease Models, Animal,
pubmed-meshheading:2570031-Female,
pubmed-meshheading:2570031-Genetic Linkage,
pubmed-meshheading:2570031-Genetic Markers,
pubmed-meshheading:2570031-Humans,
pubmed-meshheading:2570031-Hybrid Cells,
pubmed-meshheading:2570031-Male,
pubmed-meshheading:2570031-Mice,
pubmed-meshheading:2570031-Mice, Inbred C57BL,
pubmed-meshheading:2570031-Muridae,
pubmed-meshheading:2570031-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:2570031-Retinoblastoma
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pubmed:year |
1989
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pubmed:articleTitle |
The murine retinoblastoma homolog maps to chromosome 14 near Es-10.
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pubmed:affiliation |
Jackson Laboratory, Bar Harbor, Maine 04609.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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