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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1989-9-22
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pubmed:abstractText |
We isolated cDNAs encoding a 115 kd human atrial natriuretic peptide (alpha ANP) receptor (ANP-A receptor) that possesses guanylate cyclase activity, by low-stringency hybridization with sea urchin Arbacia punctulata membrane guanylate cyclase probes. The human ANP-A receptor has a 32 residue signal sequence followed by a 441 residue extracellular domain homologous to the 60 kd ANP-C receptor. A 21 residue transmembrane domain precedes a 568 residue cytoplasmic domain with homology to the protein kinase family and to a subunit of the soluble guanylate cyclase. COS-7 cells transfected with an ANP-A receptor expression vector displayed specific [125I]alpha ANP binding, and exhibited alpha ANP stimulated cGMP production. These data demonstrate a new paradigm of cellular signal transduction where extracellular ligand binding allosterically regulates cyclic nucleotide second-messenger production by a receptor cytoplasmic catalytic domain.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-2439919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-24631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-2563900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-2827195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-2837487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-2843519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-2852953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-2866981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-2871018,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-2877982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-2881352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-2887565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-2899082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-2901039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-2903071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-2936330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-2983222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-2985470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-2988123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-2992513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-2993293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-2999098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-3015690,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-3017939,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-3038873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-3130578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-3291115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-3291942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-3431465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-3453112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-3657593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-3873704,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-4001923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-4065096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-5342361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-6091631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-6150043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-6150486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-6312838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-6419347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-6852022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-7035466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-728996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2569967-822353
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0261-4189
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1377-84
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2569967-Amino Acid Sequence,
pubmed-meshheading:2569967-Animals,
pubmed-meshheading:2569967-Atrial Natriuretic Factor,
pubmed-meshheading:2569967-Base Sequence,
pubmed-meshheading:2569967-DNA,
pubmed-meshheading:2569967-Guanylate Cyclase,
pubmed-meshheading:2569967-Humans,
pubmed-meshheading:2569967-Molecular Sequence Data,
pubmed-meshheading:2569967-RNA, Messenger,
pubmed-meshheading:2569967-Receptors, Atrial Natriuretic Factor,
pubmed-meshheading:2569967-Receptors, Cell Surface,
pubmed-meshheading:2569967-Sea Urchins,
pubmed-meshheading:2569967-Second Messenger Systems,
pubmed-meshheading:2569967-Sequence Homology, Nucleic Acid
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pubmed:year |
1989
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pubmed:articleTitle |
Human atrial natriuretic peptide receptor defines a new paradigm for second messenger signal transduction.
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pubmed:affiliation |
Department of Molecular Biology, Genentech, Inc., South San Francisco, CA 94080.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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