|
rdf:type |
|
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lifeskim:mentions |
umls-concept:C0017890,
umls-concept:C0019564,
umls-concept:C0027882,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0079883,
umls-concept:C0871261,
umls-concept:C1413038,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
1-3
|
|
pubmed:dateCreated |
1989-9-15
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|
pubmed:abstractText |
When superfused onto rat hippocampal slices, glycine (0.1-0.5 mM) potentiated the depolarization induced by pressure application of NMDA in normal Krebs solution and the synaptic discharge evoked by stimulation of the Schaffer collateral-commissural inputs to the CA1 pyramidal neurons bathed in Mg2+-free media; the effects were not prevented by strychnine. In addition, glycine partially reversed the blocking effect of D-2-amino-5-phosphonovalerate (AP5) on N-methyl-D-aspartate (NMDA)-induced depolarization. These results show that glycine at relatively high concentrations potentiates the NMDA-mediated response in hippocampal slices.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
May
|
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pubmed:issn |
0304-3940
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|
pubmed:author |
|
|
pubmed:issnType |
Print
|
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pubmed:day |
22
|
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pubmed:volume |
100
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
237-42
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|
pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
|
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pubmed:year |
1989
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pubmed:articleTitle |
Glycine potentiates NMDA responses in rat hippocampal CA1 neurons.
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|
pubmed:affiliation |
Department of Pharmacology, Loyola University Stritch School of Medicine, Maywood, IL 60153.
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|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
