Linked Life Data

2568877

Source:http://linkedlifedata.com/resource/pubmed/id/2568877

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1989-8-31
pubmed:abstractText
The effects of serotonin on responses induced in Purkinje cells (PCs) by microiontophoretic administration of excitatory amino acids (EAAs) in their dendritic fields were tested in vitro by extracellular recording and by single electrode voltage clamp methods in cerebellar slices from rats aged 16-22 days. Serotonin diminished excitations produced by glutamate (Glu) and quisqualate (Quis) selectively, those caused by N-methyl-D-aspartate (NMDA) being affected much less. These suppressions of Glu- and Quis-induced responses generally occurred without there being any effect on intrinsic membrane properties of PCs, although on occasion serotonin increased membrane conductance slightly and/or induced an outward current in the recorded cells. All these effects of serotonin were maintained in the presence of tetrodotoxin and reversed upon removal of the amine. On the few occasions when serotonin enhanced Quis-induced responses, the effect was mimicked by ejection from a control solution of saline, made up at the same pH as the drug solution of serotonin.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
17
pubmed:volume
492
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
371-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Selective effects of serotonin upon excitatory amino acid-induced depolarizations of Purkinje cells in cerebellar slices from young rats.
pubmed:affiliation
Laboratoire de Neurobiologie et Neuropharmacologie du Développement, URA CNRS 1121, Université Paris-Sud, Orsay, France.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't