Linked Life Data

256872

Source:http://linkedlifedata.com/resource/pubmed/id/256872

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1979-10-17
pubmed:abstractText
Aggravation of neurological symptoms in MS patients in heating is well known. This phenomenon is explained by the change of conduction in demyelinated nerve fibers. In raised temperature conduction block occurs. The threshold of conduction block dependent on temperature, is probably proportional to the degree of demyelination. It is possible to inhibit this effect by tyrosin. This model may present a view to a part of neurophysiological mechanisms of MS, on which we possibly can take therapeutical influence. By way of a questionnaire 125 MS patients were asked about changes of their symptoms in heating or cooling. 93% had marked sensitivity to heating. In 90% worsening of neurological symptoms or of general feeling occured in a hot bath. On the other hand about half the patients reported improvement in a cold bath. Therefore we suggest, that a noticeable part of neurological deficit is reversible, if we were able to raise the threshold of conduction block, which depends on temperature, ph, electrolytes and neurotransmitters.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0015-8194
pubmed:author
pubmed:issnType
Print
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
320-5
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
[On the temperature sensitivity of multiple sclerosis patients (author's transl)].
pubmed:publicationType
Journal Article, English Abstract