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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8652
|
| pubmed:dateCreated |
1989-7-21
|
| pubmed:abstractText |
103 patients with acute airflow obstruction (56 asthma, 47 chronic obstructive pulmonary disease [COPD]) completed a double-blind trial of nebulised bronchodilator treatment in a hospital accident and emergency department. Each patient was randomised to receive either 10 mg of salbutamol nebuliser solution in 2 ml of saline or 10 mg of salbutamol in 2 ml (0.5 mg) of preservative-free ipratropium bromide. Peak flow rate (PFR) was recorded before treatment and 1 hour after beginning nebulised treatment. In 23 asthmatic patients given salbutamol alone PFR rose by a mean 31% 1 hour after treatment whereas in 33 such patients given combined treatment it rose by a mean 77% (95% confidence interval for the difference 8-84%). Patients whose PFR was below 140 l/min at entry gained maximum benefit from the combined treatment. For COPD patients the PFR rise was almost identical for both treatments. In acute asthma the immediate PFR response to a mixture of salbutamol and ipratropium bromide was better than the response to nebulised salbutamol alone. For COPD patients, the two treatments were of equal benefit.
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0140-6736
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
24
|
| pubmed:volume |
1
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1418-20
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2567431-Acute Disease,
pubmed-meshheading:2567431-Adolescent,
pubmed-meshheading:2567431-Adult,
pubmed-meshheading:2567431-Aged,
pubmed-meshheading:2567431-Aged, 80 and over,
pubmed-meshheading:2567431-Albuterol,
pubmed-meshheading:2567431-Asthma,
pubmed-meshheading:2567431-Atropine Derivatives,
pubmed-meshheading:2567431-Clinical Trials as Topic,
pubmed-meshheading:2567431-Double-Blind Method,
pubmed-meshheading:2567431-Drug Evaluation,
pubmed-meshheading:2567431-Drug Therapy, Combination,
pubmed-meshheading:2567431-Humans,
pubmed-meshheading:2567431-Ipratropium,
pubmed-meshheading:2567431-Lung Diseases, Obstructive,
pubmed-meshheading:2567431-Middle Aged,
pubmed-meshheading:2567431-Nebulizers and Vaporizers,
pubmed-meshheading:2567431-Peak Expiratory Flow Rate,
pubmed-meshheading:2567431-Random Allocation
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Nebulised salbutamol with and without ipratropium bromide in acute airflow obstruction.
|
| pubmed:affiliation |
Hope Hospital, Salford.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial
|