Linked Life Data

2567333

Source:http://linkedlifedata.com/resource/pubmed/id/2567333

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1989-7-21
pubmed:abstractText
Survival of murine lymphoblasts L5178Y-R and L5178Y-S irradiated with 60Co gamma radiation was determined. The parameters of the survival curves were D0 = 1.18 Gy, n = 1.56 and D0 = 0.55 Gy, n = 1.00 for L5178Y-R and L5178Y-S cells respectively. The sizes of DNA supercoiled domains were estimated using sedimentation of nucleoids from cells irradiated with doses from 1 to 7 Gy. These sizes were 2.44 x 10(9) and 5.13 x 10(8) Da for L5178Y-R cells and 1.30 x 10(9) and 4.07 x 10(8) Da for L5178Y-S cells. Hence, higher radiosensitivity of L5178Y-S cells was not compatible with the larger size of the DNA supercoiled domains, as suggested by Filippovich et al. (1982). We have not found any simple relation between the sizes of DNA supercoiled domains and the susceptibility of L5178Y sublines to ionizing radiation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0955-3002
pubmed:author
pubmed:issnType
Print
pubmed:volume
55
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
953-61
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Radiation sensitivities are not related to the sizes of DNA supercoiled domains in L5178Y-R and L5178Y-S cells.
pubmed:affiliation
Department of Radiobiology and Health Protection, Institute of Nuclear Chemistry and Technology, Warszawa, Poland.
pubmed:publicationType
Journal Article