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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1989-6-26
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pubmed:abstractText |
A series of 2-aryl-1- ([3-(imidazol-4-yl)propyl]guanidinylalkyl)-2,3-dihydro-4(1H)- quinazolinones were prepared starting with appropriate aminoalkyl-quinazolinones. The substances proved to be moderate H1-antagonists at the isolated guinea-pig ileum as well as H2-agonists, maximally achieving 1.6 times the activity of histamine at the isolated guinea-pig right atrium. Compounds with a three-membered carbon chain connecting the bicyclus and the guanidine system are up to 100 times more active at the atrium (chronotropic effect) than the corresponding lower homologues.
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pubmed:language |
ger
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0365-6233
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
322
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
115-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:2567156-Animals,
pubmed-meshheading:2567156-Chemical Phenomena,
pubmed-meshheading:2567156-Chemistry,
pubmed-meshheading:2567156-Guanidines,
pubmed-meshheading:2567156-Guinea Pigs,
pubmed-meshheading:2567156-Histamine H1 Antagonists,
pubmed-meshheading:2567156-Histamine H2 Antagonists,
pubmed-meshheading:2567156-Imidazoles,
pubmed-meshheading:2567156-Male,
pubmed-meshheading:2567156-Muscle, Smooth,
pubmed-meshheading:2567156-Muscle Contraction,
pubmed-meshheading:2567156-Quinazolines
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pubmed:year |
1989
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pubmed:articleTitle |
[Quinazolinones. 16. Synthesis and in vitro pharmacology of 2-aryl-1- ([3-(imidazol-4-yl)propyl]-guanidinylalkyl)-2,3-dihydro-4(1H)- quinazolinones].
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pubmed:publicationType |
Journal Article,
In Vitro,
English Abstract
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