|
rdf:type |
|
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lifeskim:mentions |
|
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pubmed:issue |
8650
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|
pubmed:dateCreated |
1989-7-6
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|
pubmed:abstractText |
The clinical and immunological evolution of lesions in cutaneous leishmaniasis was assessed after treatment with human recombinant gamma interferon (rIFN-gamma). 3 weeks after rIFN-gamma treatment of lesions due to Leishmania braziliensis guyanensis, 12/13 had become smaller compared with 6/13 control lesions; only 4 treated lesions were free of parasites. 9 of 13 L tropica lesions treated with rIFN-gamma resolved completely within 4-8 weeks of treatment. An acute inflammatory reaction around treated lesions was more common in lesions due to L tropica. There were no other local or systemic adverse reactions. Histological and immunohistochemical studies indicate that local application of rIFN-gamma enhances cell-mediated immune responses and thus promotes healing of cutaneous leishmaniasis.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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|
pubmed:issn |
0140-6736
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
10
|
|
pubmed:volume |
1
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
N
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pubmed:pagination |
1287-92
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:2566825-Acute Disease,
pubmed-meshheading:2566825-Administration, Topical,
pubmed-meshheading:2566825-Adolescent,
pubmed-meshheading:2566825-Adult,
pubmed-meshheading:2566825-Animals,
pubmed-meshheading:2566825-Antibodies, Protozoan,
pubmed-meshheading:2566825-Biopsy,
pubmed-meshheading:2566825-Brazil,
pubmed-meshheading:2566825-Clinical Trials as Topic,
pubmed-meshheading:2566825-Female,
pubmed-meshheading:2566825-HLA-DR Antigens,
pubmed-meshheading:2566825-Humans,
pubmed-meshheading:2566825-Immunity, Cellular,
pubmed-meshheading:2566825-Immunoglobulin E,
pubmed-meshheading:2566825-Injections, Subcutaneous,
pubmed-meshheading:2566825-Interferon-gamma,
pubmed-meshheading:2566825-Leishmania braziliensis,
pubmed-meshheading:2566825-Leishmaniasis,
pubmed-meshheading:2566825-Leukocyte Count,
pubmed-meshheading:2566825-Male,
pubmed-meshheading:2566825-Middle Aged,
pubmed-meshheading:2566825-Receptors, Interleukin-2,
pubmed-meshheading:2566825-Recombinant Proteins,
pubmed-meshheading:2566825-Skin,
pubmed-meshheading:2566825-Syria,
pubmed-meshheading:2566825-T-Lymphocytes,
pubmed-meshheading:2566825-Time Factors
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|
pubmed:year |
1989
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|
pubmed:articleTitle |
Effects of intradermal gamma-interferon in cutaneous leishmaniasis.
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|
pubmed:affiliation |
Landesinstitut für Tropenmedizin, Berlin, Federal Republic of Germany.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Controlled Clinical Trial
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