Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1989-6-9
pubmed:abstractText
We have compared constitutional and tumor genotypes in nine cases of hereditary Wilms tumor (WT) and in three unrelated cases of familial adrenocortical carcinoma (ADCC). Since susceptibility to these tumors can be observed in malformation syndromes associated with a constitutional deletion of band 11p13 (WT) and with a constitutional duplication of band 11p15.5 (WT, ADCC), we investigated these two candidate regions by using 11p polymorphic markers. As expected, somatic chromosomal events, resulting in a loss of heterozygosity limited to region 11p15.5, were observed in the tumor of two familial cases of adrenocortical carcinoma. Surprisingly, however, analysis of the WT of two patients with a constitutional deletion of band 11p13, associated with aniridia, genitourinary abnormalities, and mental retardation (WAGR syndrome), revealed a loss of heterozygosity limited to region 11p15.5. These data therefore suggest that observation of a specific loss of heterozygosity may not necessarily point to the site of the initial germinal mutation. Together with previous similar observations of a loss of heterozygosity limited to 11p15.5 in breast cancer and in rhabdomyosarcoma, our data suggest that region 11p15.5 may carry a non-tissue-specific gene that could be involved in genetic predisposition, in tumor progression, or in both.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2566168-1195397, http://linkedlifedata.com/resource/pubmed/commentcorrection/2566168-127562, http://linkedlifedata.com/resource/pubmed/commentcorrection/2566168-14231762, http://linkedlifedata.com/resource/pubmed/commentcorrection/2566168-16593532, http://linkedlifedata.com/resource/pubmed/commentcorrection/2566168-225131, http://linkedlifedata.com/resource/pubmed/commentcorrection/2566168-2841597, http://linkedlifedata.com/resource/pubmed/commentcorrection/2566168-2848199, http://linkedlifedata.com/resource/pubmed/commentcorrection/2566168-2848200, http://linkedlifedata.com/resource/pubmed/commentcorrection/2566168-2886917, http://linkedlifedata.com/resource/pubmed/commentcorrection/2566168-2886918, http://linkedlifedata.com/resource/pubmed/commentcorrection/2566168-291033, http://linkedlifedata.com/resource/pubmed/commentcorrection/2566168-2989708, http://linkedlifedata.com/resource/pubmed/commentcorrection/2566168-2991766, http://linkedlifedata.com/resource/pubmed/commentcorrection/2566168-2994545, http://linkedlifedata.com/resource/pubmed/commentcorrection/2566168-3000666, http://linkedlifedata.com/resource/pubmed/commentcorrection/2566168-3388033, http://linkedlifedata.com/resource/pubmed/commentcorrection/2566168-3507274, http://linkedlifedata.com/resource/pubmed/commentcorrection/2566168-3507285, http://linkedlifedata.com/resource/pubmed/commentcorrection/2566168-3605097, http://linkedlifedata.com/resource/pubmed/commentcorrection/2566168-3614355, http://linkedlifedata.com/resource/pubmed/commentcorrection/2566168-3657988, http://linkedlifedata.com/resource/pubmed/commentcorrection/2566168-3659909, http://linkedlifedata.com/resource/pubmed/commentcorrection/2566168-3876070, http://linkedlifedata.com/resource/pubmed/commentcorrection/2566168-3983638, http://linkedlifedata.com/resource/pubmed/commentcorrection/2566168-4347033, http://linkedlifedata.com/resource/pubmed/commentcorrection/2566168-5279523, http://linkedlifedata.com/resource/pubmed/commentcorrection/2566168-6094958, http://linkedlifedata.com/resource/pubmed/commentcorrection/2566168-6265341, http://linkedlifedata.com/resource/pubmed/commentcorrection/2566168-6325936, http://linkedlifedata.com/resource/pubmed/commentcorrection/2566168-6325937, http://linkedlifedata.com/resource/pubmed/commentcorrection/2566168-6325938, http://linkedlifedata.com/resource/pubmed/commentcorrection/2566168-6325939, http://linkedlifedata.com/resource/pubmed/commentcorrection/2566168-6633649, http://linkedlifedata.com/resource/pubmed/commentcorrection/2566168-6766207
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
86
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3247-51
pubmed:dateRevised
2010-9-9
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Tumor-specific loss of 11p15.5 alleles in del11p13 Wilms tumor and in familial adrenocortical carcinoma.
pubmed:affiliation
Institut National de la Santé et de la Recherche Médicale Unité 73, Château de Longchamp, Bois de Boulogne, Paris, France.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't