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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1989-6-6
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pubmed:abstractText |
Na+-selective, double-barrelled microelectrodes were used to measure intracellular Na+ activity (aiNa) and membrane potential (Em) in neuropile glial cells of isolated segmental ganglia in the leech Hirudo medicinalis. Bath application of glutamate (10(-3) M) resulted in membrane depolarizations of about 5 mV and a concomitant increase of aiNa by between 2 and 10 mM. Kainate (10(-4) M) elicited depolarizations of up to 40 mV amplitude followed by a prominent after hyperpolarization. During kainate, aiNa increased by 7 to 25 mM. In contrast to glutamate, an initial decrease of aiNa was detected during the action of kainate. N-methyl-D-aspartate (NMDA, 10(-5)-10(-3) M) had no effect of Em and aiNa. The results indicate that leech glial cells have a kainate-preferring non-NMDA glutamate receptor.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0894-1491
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
51-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2565287-Animals,
pubmed-meshheading:2565287-Glutamates,
pubmed-meshheading:2565287-Glutamic Acid,
pubmed-meshheading:2565287-Kainic Acid,
pubmed-meshheading:2565287-Leeches,
pubmed-meshheading:2565287-Membrane Potentials,
pubmed-meshheading:2565287-Neuroglia,
pubmed-meshheading:2565287-Sodium
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pubmed:year |
1989
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pubmed:articleTitle |
Glutamate and kainate increase intracellular sodium activity in leech neuropile glial cells.
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pubmed:affiliation |
Physiologisches Institut, Zentrum Physiologie und Pathophysiologie, Georg-August-Universität, Göttingen, Federal Republic of Germany.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|