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pubmed-article:2563395pubmed:abstractTextThe technique of premature chromosome condensation (PCC) was used to compare the early formation of chromosome breaks in non-cycling HF19 human diploid fibroblasts when irradiated with slow alpha particles (3.2 MeV, 128 keV micron-1) or 250 kVP X-rays. For both radiations the production of PCC breaks increased approximately linearly with dose. The production coefficient for alpha particles was 12.5 +/- 0.6 per cent per Gy and for X-rays it was 5.8 +/- 0.2 per cell per Gy. Hence, the relative biological effectiveness (RBE) of the alpha particles was 2.16 +/- 0.13. This is smaller than reported values of the RBE for the production of chromosome-type exchange aberrations by slow alpha particles. This implies that there is a difference, spatial or qualitative, in the initial breaks produced by the densely ionizing alpha particle tracks and the more sparsely ionizing electron tracks from the X-rays.lld:pubmed
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pubmed-article:2563395pubmed:authorpubmed-author:GoodheadD TDTlld:pubmed
pubmed-article:2563395pubmed:authorpubmed-author:BedfordJ SJSlld:pubmed
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pubmed-article:2563395pubmed:volume55lld:pubmed
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pubmed-article:2563395pubmed:pagination211-6lld:pubmed
pubmed-article:2563395pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:2563395pubmed:year1989lld:pubmed
pubmed-article:2563395pubmed:articleTitleBreakage of human interphase chromosomes by alpha particles and X-rays.lld:pubmed
pubmed-article:2563395pubmed:affiliationDepartment of Radiology and Radiation Biology, Colorado State University, Fort Collins 80523.lld:pubmed
pubmed-article:2563395pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2563395pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:2563395pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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