Linked Life Data

2560687

Source:http://linkedlifedata.com/resource/pubmed/id/2560687

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1990-4-16
pubmed:abstractText
In order to evaluate which of human (h) corticotrophin-like intermediary lobe peptide (CLIP) or h beta-melanocyte stimulating hormone5-22 (h beta MSH5-22) was the better marker of alternate pro-opiomelanocortin (POMC) processing, both peptides were simultaneously sought in the same tissue extracts from a normal human pituitary, six corticotrophic adenomas, and four non-pituitary tumours responsible for an ectopic ACTH syndrome. Human CLIP was detected using a combination of gel exclusion chromatography and two different radioimmunoassays (RIAs): a mid-ACTH RIA which recognized ACTH but not CLIP, and a COOH-ACTH RIA which recognized both molecules. Human beta MSH5-22 had been measured previously. Neither hCLIP nor h beta MSH5-22 were detected in the normal or tumoural pituitaries. The four non-pituitary tumours, in contrast, contained both peptides; the hCLIP and h beta MSH5-22 ratios (CLIP/CLIP + ACTH and h beta MSH5-22/h beta MSH5-22 + h gamma LPH) ranged from 40 to 94% and from 24 to 46%, respectively. In a given tissue the hCLIP ratio was always higher than the h beta MSH5-22 ratio. hCLIP is therefore the better marker of alternate POMC processing.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0300-0664
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
691-700
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:2560687-ACTH Syndrome, Ectopic, pubmed-meshheading:2560687-Adenoma, pubmed-meshheading:2560687-Adrenocorticotropic Hormone, pubmed-meshheading:2560687-Bronchial Neoplasms, pubmed-meshheading:2560687-Carcinoid Tumor, pubmed-meshheading:2560687-Chromatography, Gel, pubmed-meshheading:2560687-Corticotropin-Like Intermediate Lobe Peptide, pubmed-meshheading:2560687-Humans, pubmed-meshheading:2560687-Melanocyte-Stimulating Hormones, pubmed-meshheading:2560687-Paraneoplastic Endocrine Syndromes, pubmed-meshheading:2560687-Peptide Fragments, pubmed-meshheading:2560687-Pituitary Neoplasms, pubmed-meshheading:2560687-Pro-Opiomelanocortin, pubmed-meshheading:2560687-Radioimmunoassay, pubmed-meshheading:2560687-Thymus Neoplasms, pubmed-meshheading:2560687-Tumor Markers, Biological
pubmed:year
1989
pubmed:articleTitle
Corticotrophin-like intermediary lobe peptide as a marker of alternate pro-opiomelanocortin processing in ACTH-producing non-pituitary tumours.
pubmed:affiliation
Centre de Recherches sur les Maladies Endocriniennes, Hôpital Cochin, Paris, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't