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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
11
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pubmed:dateCreated |
1990-3-14
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pubmed:abstractText |
A facile synthesis of adenosine 3', 5'-cyclic methylphosphonate (1) and 3', 5'-cyclic methylphosphonothioate (2) was accomplished by treatment of 2'-protected adenosine with O,O-bis (1-benzotriazolyl) methylphosphonate or O,O-bis (1-benzotriazolyl) methylphosphonothioate under mild conditions, respectively. The ability of the compounds to inhibit DNA synthesis in mice hepatoma was tested. A pair of diasteromers of 2'-protected (1) was separated and the configuration at the phosphorus atom was identified.
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pubmed:language |
chi
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0513-4870
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
24
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
872-6
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:2559579-Animals,
pubmed-meshheading:2559579-Antineoplastic Agents,
pubmed-meshheading:2559579-Carcinoma, Ehrlich Tumor,
pubmed-meshheading:2559579-Chemical Phenomena,
pubmed-meshheading:2559579-Chemistry,
pubmed-meshheading:2559579-Cyclic AMP,
pubmed-meshheading:2559579-DNA, Neoplasm,
pubmed-meshheading:2559579-Mice,
pubmed-meshheading:2559579-Organothiophosphorus Compounds,
pubmed-meshheading:2559579-Tumor Cells, Cultured
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pubmed:year |
1989
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pubmed:articleTitle |
[A facile synthesis of adenosine 3', 5'-cyclic methylphosphonate and methylphosphonothioate].
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pubmed:publicationType |
Journal Article,
English Abstract,
Research Support, Non-U.S. Gov't
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