| pubmed-article:2559217 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2559217 | lifeskim:mentions | umls-concept:C0086943 | lld:lifeskim |
| pubmed-article:2559217 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:2559217 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:2559217 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:2559217 | lifeskim:mentions | umls-concept:C0021083 | lld:lifeskim |
| pubmed-article:2559217 | lifeskim:mentions | umls-concept:C1522424 | lld:lifeskim |
| pubmed-article:2559217 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:2559217 | lifeskim:mentions | umls-concept:C0507110 | lld:lifeskim |
| pubmed-article:2559217 | lifeskim:mentions | umls-concept:C0017638 | lld:lifeskim |
| pubmed-article:2559217 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:2559217 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:2559217 | pubmed:dateCreated | 1990-3-2 | lld:pubmed |
| pubmed-article:2559217 | pubmed:abstractText | A cultured glioma cell line, SR-B10.A, which was derived from a brain tumor induced in an adult female B10.A mouse by Rous sarcoma virus (RSV), has been established. The morphological appearance of the tumor produced by s.c. inoculating SR-B10.A cells was analogous to an astrocytoma of human glioma. Glial fibrillary acidic protein as well as S-100 protein was positive in these SR-B10.A tumor cells. A population doubling time of the cultured cells was 18.5 hours. Chromosomal analysis revealed a defect in one of the sex chromosomes. Integration of RSV genome was proven to be positive in SR-B10.A cells. It was possible to generate cytotoxic effector cells in the syngeneic B10.A mouse against SR-B10.A. The tumor-bearing syngeneic hosts harbored a suppressor activity in the splenocytes. Although recombinant human tumor necrosis factor (rH-TNF) had no growth inhibitory effect on the SR-B10.A cells in vitro, the s.c. implanted and growing tumor regressed when rH-TNF was administered intratumorally several times. In addition, this anti-tumor effect was completely abrogated when the host mice were treated with wholebody x-ray irradiation prior to the tumor cells inoculation. In contrast, neither rH-TNF (i.v.) nor cyclophosphamide (i.p.) induced the regression of SR-B10.A, indicating that efficacy of the locally administered rH-TNF is dependent on the host immune mechanism. These results suggest that SR-B10.A is a potentially useful tumor model in evaluating efficacy of immunomodulators. | lld:pubmed |
| pubmed-article:2559217 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2559217 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2559217 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2559217 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2559217 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2559217 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2559217 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2559217 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:2559217 | pubmed:issn | 0021-5031 | lld:pubmed |
| pubmed-article:2559217 | pubmed:author | pubmed-author:SakamotoKK | lld:pubmed |
| pubmed-article:2559217 | pubmed:author | pubmed-author:NagamachiYY | lld:pubmed |
| pubmed-article:2559217 | pubmed:author | pubmed-author:NakaneMM | lld:pubmed |
| pubmed-article:2559217 | pubmed:author | pubmed-author:HoshinoHH | lld:pubmed |
| pubmed-article:2559217 | pubmed:author | pubmed-author:KiuchiYY | lld:pubmed |
| pubmed-article:2559217 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2559217 | pubmed:volume | 59 | lld:pubmed |
| pubmed-article:2559217 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2559217 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2559217 | pubmed:pagination | 173-80 | lld:pubmed |
| pubmed-article:2559217 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2559217 | pubmed:meshHeading | pubmed-meshheading:2559217-... | lld:pubmed |
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| pubmed-article:2559217 | pubmed:meshHeading | pubmed-meshheading:2559217-... | lld:pubmed |
| pubmed-article:2559217 | pubmed:meshHeading | pubmed-meshheading:2559217-... | lld:pubmed |
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| pubmed-article:2559217 | pubmed:meshHeading | pubmed-meshheading:2559217-... | lld:pubmed |
| pubmed-article:2559217 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2559217 | pubmed:articleTitle | Potential usefulness of a cultured glioma cell line induced by Rous sarcoma virus in B10.A mouse as an immunotherapy model. | lld:pubmed |
| pubmed-article:2559217 | pubmed:affiliation | Department of Surgery, Gunma University School of Medicine, Maebashi, Japan. | lld:pubmed |
| pubmed-article:2559217 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2559217 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
