| pubmed-article:2558966 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2558966 | lifeskim:mentions | umls-concept:C0024660 | lld:lifeskim |
| pubmed-article:2558966 | lifeskim:mentions | umls-concept:C1253959 | lld:lifeskim |
| pubmed-article:2558966 | lifeskim:mentions | umls-concept:C0205145 | lld:lifeskim |
| pubmed-article:2558966 | lifeskim:mentions | umls-concept:C0162796 | lld:lifeskim |
| pubmed-article:2558966 | lifeskim:mentions | umls-concept:C0036576 | lld:lifeskim |
| pubmed-article:2558966 | lifeskim:mentions | umls-concept:C0600436 | lld:lifeskim |
| pubmed-article:2558966 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:2558966 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:2558966 | pubmed:dateCreated | 1990-3-1 | lld:pubmed |
| pubmed-article:2558966 | pubmed:abstractText | SV40 early pre-mRNA is alternatively spliced to produce large T and small t mRNAs by use of different 5'-splice sites and a shared 3'-splice site. The large T splicing pathway uses multiple lariat branch sites, whereas small t splicing, constrained by its small intron size, can use only one. We exploited this situation to test the hypothesis that RNA-RNA base pairing between U2 snRNA and the branch site sequence is important in mammalian pre-mRNA splicing by constructing and analyzing several mutations in the small t pre-mRNA branch site (UUCUAAU). All of the mutations resulted in substantial decreases in small t splicing relative to large T. To test whether these effects resulted from decreased base pairing with U2 snRNA, compensatory mutations were introduced at the appropriate positions (nucleotides 34-36) in a cloned human U2 gene. All branch site mutations tested (four separate single base substitutions and two triple mutations) were suppressed (i.e., small t splicing was increased) by the appropriate U2 mutations. These results establish that recognition of the poorly conserved mammalian pre-mRNA branch site sequence by U2 snRNP can involve base-pairing. | lld:pubmed |
| pubmed-article:2558966 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2558966 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2558966 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2558966 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2558966 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2558966 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2558966 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:2558966 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:2558966 | pubmed:author | pubmed-author:WuJJ | lld:pubmed |
| pubmed-article:2558966 | pubmed:author | pubmed-author:ManleyJ LJL | lld:pubmed |
| pubmed-article:2558966 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2558966 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:2558966 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2558966 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2558966 | pubmed:pagination | 1553-61 | lld:pubmed |
| pubmed-article:2558966 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2558966 | pubmed:meshHeading | pubmed-meshheading:2558966-... | lld:pubmed |
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| pubmed-article:2558966 | pubmed:meshHeading | pubmed-meshheading:2558966-... | lld:pubmed |
| pubmed-article:2558966 | pubmed:meshHeading | pubmed-meshheading:2558966-... | lld:pubmed |
| pubmed-article:2558966 | pubmed:meshHeading | pubmed-meshheading:2558966-... | lld:pubmed |
| pubmed-article:2558966 | pubmed:meshHeading | pubmed-meshheading:2558966-... | lld:pubmed |
| pubmed-article:2558966 | pubmed:meshHeading | pubmed-meshheading:2558966-... | lld:pubmed |
| pubmed-article:2558966 | pubmed:meshHeading | pubmed-meshheading:2558966-... | lld:pubmed |
| pubmed-article:2558966 | pubmed:meshHeading | pubmed-meshheading:2558966-... | lld:pubmed |
| pubmed-article:2558966 | pubmed:meshHeading | pubmed-meshheading:2558966-... | lld:pubmed |
| pubmed-article:2558966 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2558966 | pubmed:articleTitle | Mammalian pre-mRNA branch site selection by U2 snRNP involves base pairing. | lld:pubmed |
| pubmed-article:2558966 | pubmed:affiliation | Department of Biological Sciences, Columbia University, New York, New York 10027. | lld:pubmed |
| pubmed-article:2558966 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2558966 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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