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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1990-1-23
|
| pubmed:abstractText |
Diethyldithiocarbamate (DDC), an inhibitor of superoxide dismutase, produced ulceration in the proximal duodenum of rats, and erosions or ulcers in the stomach. DDC given s. c. at 1.5 g/kg increased duodenal and gastric vascular permeability, and reduced blood flow. The decrease in gastric blood flow caused by DDC was attenuated by pretreatment with superoxide dismutase, and significantly inhibited by a xanthine oxidase inhibitor, allopurinol. It is suggested that the superoxide and other radicals damage the mucosal vasculature, and play a role in the pathogenesis of gastric and duodenal mucosal lesions.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0085-5928
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
162
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
108-11
|
| pubmed:dateRevised |
2008-2-13
|
| pubmed:meshHeading |
pubmed-meshheading:2556783-Animals,
pubmed-meshheading:2556783-Capillary Permeability,
pubmed-meshheading:2556783-Ditiocarb,
pubmed-meshheading:2556783-Duodenal Ulcer,
pubmed-meshheading:2556783-Duodenum,
pubmed-meshheading:2556783-Gastric Mucosa,
pubmed-meshheading:2556783-Intestinal Mucosa,
pubmed-meshheading:2556783-Male,
pubmed-meshheading:2556783-Rats,
pubmed-meshheading:2556783-Rats, Inbred Strains,
pubmed-meshheading:2556783-Regional Blood Flow,
pubmed-meshheading:2556783-Stomach Ulcer,
pubmed-meshheading:2556783-Time Factors
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Effect of diethyldithiocarbamate on gastric and duodenal mucosal blood flow and vascular permeability in rats.
|
| pubmed:affiliation |
Department of Geriatric Medicine, Faculty of Medicine, Kyoto University, Japan.
|
| pubmed:publicationType |
Journal Article
|