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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1990-1-25
|
| pubmed:abstractText |
The biological activity of beta-casein derived beta-casomorphin peptides was evaluated by injecting bovine beta-casomorphin-5 (Tyr-Pro-Phe-Pro-Gly), the homologous sequence in human beta-casein (Tyr-Pro-Phe-Val-Glu) and the corresponding N-terminal tetrapeptides into the left substantia nigra of rats. Their ability to produce rotational behaviour was compared to that produced by three reference compounds, morphine, D-ala2D-leu5 enkephalin and U50,488H, ligands for mu, delta and kappa types of opioid receptors, respectively. The relative potencies of beta-casomorphins and morphine were compared to those tested in two in vitro assays for opioid activity: (1) inhibition of the electrically induced contraction of the isolated myenteric plexus-longitudinal muscle of the guinea-pig ileum and (2) displacement of 3H-dihydromorphine binding to brain membranes. The same ranking order of potency was found in all three assays, the peptides from human beta-casein being about 10-fold less potent than those from bovine beta-casein. The effects of both morphine and bovine beta-casomorphin-5 in producing rotational behaviour were antagonized by naloxone; however, approximately 10-fold more naloxone was required to antagonize the beta-casomorphin-5 effect than that of morphine. The present data are discussed in the light of the recent observation that high concentrations of beta-casomorphin-like peptides are found in the cerebrospinal fluid and plasma of women with postpartum psychosis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3,4-Dichloro-N-methyl-N-(2-(1-pyrrol...,
http://linkedlifedata.com/resource/pubmed/chemical/Endorphins,
http://linkedlifedata.com/resource/pubmed/chemical/Enkephalin, Leucine,
http://linkedlifedata.com/resource/pubmed/chemical/Enkephalin, Leucine-2-Alanine,
http://linkedlifedata.com/resource/pubmed/chemical/Morphine,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrrolidines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid,
http://linkedlifedata.com/resource/pubmed/chemical/beta-casomorphins,
http://linkedlifedata.com/resource/pubmed/chemical/enkephalinamide-Leu, Ala(2)-
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0033-3158
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
99
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
357-61
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2556724-3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benz...,
pubmed-meshheading:2556724-Animals,
pubmed-meshheading:2556724-Cattle,
pubmed-meshheading:2556724-Endorphins,
pubmed-meshheading:2556724-Enkephalin, Leucine,
pubmed-meshheading:2556724-Enkephalin, Leucine-2-Alanine,
pubmed-meshheading:2556724-Guinea Pigs,
pubmed-meshheading:2556724-Humans,
pubmed-meshheading:2556724-Ileum,
pubmed-meshheading:2556724-Injections,
pubmed-meshheading:2556724-Male,
pubmed-meshheading:2556724-Mitochondria,
pubmed-meshheading:2556724-Morphine,
pubmed-meshheading:2556724-Muscle, Smooth,
pubmed-meshheading:2556724-Pyrrolidines,
pubmed-meshheading:2556724-Rats,
pubmed-meshheading:2556724-Rats, Inbred Strains,
pubmed-meshheading:2556724-Receptors, Opioid,
pubmed-meshheading:2556724-Rotation,
pubmed-meshheading:2556724-Stereotyped Behavior,
pubmed-meshheading:2556724-Substantia Nigra
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Rotational behaviour produced by intranigral injections of bovine and human beta-casomorphins in rats.
|
| pubmed:affiliation |
Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden.
|
| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|