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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1989-12-27
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pubmed:abstractText |
The DA strain and other members of the TO subgroup of Theiler's murine encephalomyelitis viruses cause a persistent demyelinating infection, whereas the GDVII strain and other GDVII subgroup strains cause an acute lethal polioencephalomyelitis. We generated an infectious DA cDNA clone inserted into a transcription vector. Virus derived from transfection of transcripts produced a demyelinating disease indistinguishable from that of wild-type virus. The infectious clone provides a critical reagent for the production of interstrain recombinant viruses to help identify genetic loci responsible for the biological activities of the strains.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2555569-2457118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2555569-2476574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2555569-2536823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2555569-2543264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2555569-2555559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2555569-2578578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2555569-2821576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2555569-2834872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2555569-3003384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2555569-3010307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2555569-3031587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2555569-6243340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2555569-6275104
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5492-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2555569-Animals,
pubmed-meshheading:2555569-Base Sequence,
pubmed-meshheading:2555569-Cloning, Molecular,
pubmed-meshheading:2555569-DNA, Viral,
pubmed-meshheading:2555569-Enterovirus,
pubmed-meshheading:2555569-Genetic Vectors,
pubmed-meshheading:2555569-L Cells (Cell Line),
pubmed-meshheading:2555569-Maus Elberfeld virus,
pubmed-meshheading:2555569-Mice,
pubmed-meshheading:2555569-Molecular Sequence Data,
pubmed-meshheading:2555569-Plasmids,
pubmed-meshheading:2555569-Restriction Mapping,
pubmed-meshheading:2555569-Spinal Cord,
pubmed-meshheading:2555569-Transcription, Genetic,
pubmed-meshheading:2555569-Transfection,
pubmed-meshheading:2555569-Virulence
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pubmed:year |
1989
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pubmed:articleTitle |
Infectious cDNA clones of the DA strain of Theiler's murine encephalomyelitis virus.
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pubmed:affiliation |
Department of Neurology, University of Chicago Pritzker School of Medicine, Illinois 60637.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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