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Predicate | Object |
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rdf:type | |
lifeskim:mentions |
umls-concept:C0000769,
umls-concept:C0006882,
umls-concept:C0014792,
umls-concept:C0029904,
umls-concept:C0030705,
umls-concept:C0036667,
umls-concept:C0085580,
umls-concept:C0302350,
umls-concept:C0312418,
umls-concept:C0542341,
umls-concept:C0871261,
umls-concept:C1159690,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
9
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pubmed:dateCreated |
1989-11-28
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pubmed:abstractText |
The presence of Na+ transport abnormalities (decreased affinity of the Na+/K+ pump or the Na+, K+ cotransport for internal Na+, increased Na+:Li+ countertransport, increased Na+ leak), Na+ content, Na+/K+ pump activity and sensitivity to ouabain were investigated in erythrocytes from 13 patients with essential hypertension. According to the presence or absence of Na+ transport abnormalities, the patients were divided into two groups: TrNa(+) (n = 9) and TrNa(-) (n = 4) respectively. Compared with TrNa(-) patients, TrNa(+) patients were characterized by: (i) a higher arterial pressure (131.4 +/- 11.8 vs 110.0 +/- 13.2 mmHg, p less than 0.05), (ii) an increased erythrocyte Na+ content (8.9 +/- 1.0 vs 6.3 +/- 0.8 mmol/l.cells, p less than 0.01) associated with (iii) a decreased rate constant of Na+/K+ pump activity (235 +/- 26 vs 309 +/- 45 h-1, p less than 0.05) and (iv) a higher sensitivity to ouabain (0.76 +/- 0.23 vs 1.12 +/- 0.26 microM, p less than 0.05). Oral administration of canrenone 50 mg per day during 7 weeks decreased mean arterial pressure by 10-30 mmHg in 6 out of the 9 TrNa(+) patients. Conversely, it decreased mean arterial pressure in only one out of the 4 TrNa(-) patients. The hypotensive effect of canrenone in TrNa(+) patients was not associated with normalization of their Na+/K+ pump activity. Canrenone did not modify the sensitivity to ouabain of either the TrNa(+) or the TrNa(-) patients. Before treatment, acute injection of ouabain provoked an inhibition of the erythrocyte Na+/K+ pump, without any change in Na+ content.(ABSTRACT TRUNCATED AT 250 WORDS)
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pubmed:language |
fre
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0003-9683
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1603-7
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pubmed:dateRevised |
2009-2-13
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pubmed:meshHeading |
pubmed-meshheading:2554840-Biological Transport,
pubmed-meshheading:2554840-Canrenone,
pubmed-meshheading:2554840-Erythrocytes,
pubmed-meshheading:2554840-Female,
pubmed-meshheading:2554840-Humans,
pubmed-meshheading:2554840-Hypertension,
pubmed-meshheading:2554840-Male,
pubmed-meshheading:2554840-Middle Aged,
pubmed-meshheading:2554840-Ouabain,
pubmed-meshheading:2554840-Pregnadienes,
pubmed-meshheading:2554840-Sodium Channels,
pubmed-meshheading:2554840-Time Factors
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pubmed:year |
1989
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pubmed:articleTitle |
[Therapeutic response to canrenone of patients with essential hypertension as a function of sodium transport anomalies and ouabain sensitivity of erythrocytes].
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pubmed:affiliation |
INSERM U 7, hôpital Necker, Paris.
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pubmed:publicationType |
Journal Article,
English Abstract
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