Linked Life Data

2554060

Source:http://linkedlifedata.com/resource/pubmed/id/2554060

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1989-12-21
pubmed:abstractText
The influence of dietary fat on recombinant human tumor necrosis factor-alpha (rHuTNF-alpha)-associated vascular endothelial injury in mice was examined. Histopathologic evaluation showed that greater injury was consistently observed in the uterus characterized by necrosis of endothelial cells lining small vessels in the endometrium and accompanied by multifocal hemorrhage and inflammatory cell accumulation. Mice fed standard animal diet, high corn oil diet, or high menhaden oil diet showed no differences in their susceptibility to the acute injury caused by rHuTNF-alpha injected alone or in combination with recombinant murine interferon-gamma. These results indicate that uterine endothelium may be a more sensitive target for rHuTNF-alpha-mediated endothelial injury and that high menhaden oil diet does not protect against tissue injury associated with the administration of rHuTNF-alpha alone or in combination with recombinant murine interferon-gamma.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0023-6837
pubmed:author
pubmed:issnType
Print
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
564-70
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Tumor necrosis factor-alpha-associated uterine endothelial injury in vivo. Influence of dietary fat.
pubmed:affiliation
Institute of Cancer Research, University of Trondheim, Norway.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't