Linked Life Data

2553905

Source:http://linkedlifedata.com/resource/pubmed/id/2553905

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-12-15
pubmed:abstractText
We assessed the osteoclast-like giant cells in a giant cell-rich variant of malignant fibrous histiocytoma (MFH) for characteristics which are specific for osteoclasts, including excavation of bone and binding of osteoclast-specific monoclonal antibodies. Excavations characteristic of osteoclastic activity were found when the bone slices were inspected in the scanning electron microscope after incubation. Two monoclonal antibodies which bind specifically to osteoclasts showed strong membrane reactivity. These results provide strong evidence for the osteoclastic nature of the giant cells in this variant of the MFH. Osteoblasts are known to control the function of the osteoclast, and since there is bone formation present in at least half of the giant cell-rich variant of MFH it may be that it is the cells with properties peculiar to osteoblasts within the tumour which are responsible for the recruitment of the osteoclasts.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-3417
pubmed:author
pubmed:issnType
Print
pubmed:volume
159
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
53-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Osteoclasts are present in the giant cell variant of malignant fibrous histiocytoma.
pubmed:affiliation
Department of Histopathology, St George's Hospital Medical School, London, U.K.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't