Linked Life Data

2553852

Source:http://linkedlifedata.com/resource/pubmed/id/2553852

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-11-27
pubmed:abstractText
Endogenous ecotropic MuLV proviral loci are acquired by the progeny of some [SWR/J x (SWR/J x RJ/J)F1] N2 hybrid females obtained by two successive backcrosses of RF/J mice onto the SWR/J background. This results most likely from an infection of early embryos or oocytes by MuLV particles originating from maternal tissues. However, the time and site of infection are not yet known. Using oviductal transfers of embryos at the one-cell stage, we show here that three of 88 N3 embryos from [SWR/J x (SWR/J x RF/J)F1] N2 hybrid females transferred to virus-free foster mothers harbored new proviral integrations, whereas none of 61 SWR/J embryos transferred to [SWR/J x (SWR/J x RF/J)F1] N2 hybrid females had acquired any proviruses. These data support the infection of oocyte and/or early one-cell embryo as the initial event leading to new proviral insertions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-104X
pubmed:author
pubmed:issnType
Print
pubmed:volume
252
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
96-100
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Acquisition of endogenous ecotropic MuLV can occur before the late one-cell stage in the genital tract of SWR/J-RF/J hybrid females.
pubmed:affiliation
Unité de Génétique Cellulaire du Collège de France, Paris.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't