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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1989-11-9
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pubmed:abstractText |
The Shaker locus of Drosophila melanogaster encodes a family of A-type potassium channel subunits. Shaker mutants behave as antimorphs in gene dosage tests. This behaviour is due to the production of truncated A-channel subunits. We propose that they interfere with the function of their normal counterpart by forming multimeric A-channel structures. This hypothesis was tested by constructing transgenic flies carrying a heat-inducible gene encoding a truncated A-type potassium channel subunit together with a normal wild type doses of A-type potassium channel subunits. The altered subunit leads at larval, pupal or adult stages to the transformation of wild type into Shaker flies. The transformed flies exhibited a heat-inducible abnormal leg shaking behaviour and a heat-inducible facilitated neurotransmitter release at larval neuromuscular junctions. By the overexpression of an aberrant A-channel subunit the normal behaviour of transgenic D. melanogaster can be altered in a predictable way.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2551680-16453654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2551680-16453805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2551680-16593105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2551680-20636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2551680-2412760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2551680-2413182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2551680-2423005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2551680-2431384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2551680-2434020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2551680-2437260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2551680-2448635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2551680-2448636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2551680-2456579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2551680-2456921,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/2551680-2469181,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/2551680-3108854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2551680-322279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2551680-3272175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2551680-3272184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2551680-3821869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2551680-3936906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2551680-5807804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2551680-6289436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2551680-6304288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2551680-6327157,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/2551680-6954549
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0261-4189
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2359-64
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pubmed:dateRevised |
2010-9-9
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pubmed:meshHeading |
pubmed-meshheading:2551680-Amino Acid Sequence,
pubmed-meshheading:2551680-Animals,
pubmed-meshheading:2551680-Animals, Genetically Modified,
pubmed-meshheading:2551680-Base Sequence,
pubmed-meshheading:2551680-DNA Transposable Elements,
pubmed-meshheading:2551680-Drosophila melanogaster,
pubmed-meshheading:2551680-Exons,
pubmed-meshheading:2551680-Gene Expression Regulation,
pubmed-meshheading:2551680-Heat-Shock Proteins,
pubmed-meshheading:2551680-Hot Temperature,
pubmed-meshheading:2551680-Molecular Sequence Data,
pubmed-meshheading:2551680-Mutation,
pubmed-meshheading:2551680-Neuromuscular Junction,
pubmed-meshheading:2551680-Phenotype,
pubmed-meshheading:2551680-Potassium Channels,
pubmed-meshheading:2551680-Transcription, Genetic,
pubmed-meshheading:2551680-Transformation, Genetic
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pubmed:year |
1989
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pubmed:articleTitle |
The interference of truncated with normal potassium channel subunits leads to abnormal behaviour in transgenic Drosophila melanogaster.
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pubmed:affiliation |
Lehrstuhl für Biochemie, Ruhr-Universität Bochum, FRG.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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