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pubmed-article:2551462pubmed:abstractTextChronic administration of mianserin induced an increase in the density of [3H] prazosin binding sites (23%) in membranes and in the maximal noradrenaline stimulation of phosphoinositide breakdown (81%) in slices from rat brain cortex. In contrast, a similar treatment with protryptiline did not induce any significant changes. These findings suggest that the effects of antidepressant drugs on rat brain cortical alpha 1-adrenoceptors may depend on the characteristics of the drug used.lld:pubmed
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pubmed-article:2551462pubmed:articleTitleDifferential effects of chronic treatment with mianserin and protryptiline on rat brain cortical alpha 1-adrenoceptors.lld:pubmed
pubmed-article:2551462pubmed:affiliationDepartament de Farmacologia i Psiquiatria, Universitat Autònoma de Barcelona, Spain.lld:pubmed
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