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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1989-11-17
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pubmed:abstractText |
Chronic administration of mianserin induced an increase in the density of [3H] prazosin binding sites (23%) in membranes and in the maximal noradrenaline stimulation of phosphoinositide breakdown (81%) in slices from rat brain cortex. In contrast, a similar treatment with protryptiline did not induce any significant changes. These findings suggest that the effects of antidepressant drugs on rat brain cortical alpha 1-adrenoceptors may depend on the characteristics of the drug used.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0006-8993
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
498
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
366-70
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2551462-Animals,
pubmed-meshheading:2551462-Cerebral Cortex,
pubmed-meshheading:2551462-Dibenzocycloheptenes,
pubmed-meshheading:2551462-Male,
pubmed-meshheading:2551462-Mianserin,
pubmed-meshheading:2551462-Norepinephrine,
pubmed-meshheading:2551462-Phosphatidylinositols,
pubmed-meshheading:2551462-Prazosin,
pubmed-meshheading:2551462-Protriptyline,
pubmed-meshheading:2551462-Rats,
pubmed-meshheading:2551462-Rats, Inbred Strains,
pubmed-meshheading:2551462-Receptors, Adrenergic, alpha,
pubmed-meshheading:2551462-Time Factors
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pubmed:year |
1989
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pubmed:articleTitle |
Differential effects of chronic treatment with mianserin and protryptiline on rat brain cortical alpha 1-adrenoceptors.
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pubmed:affiliation |
Departament de Farmacologia i Psiquiatria, Universitat Autònoma de Barcelona, Spain.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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