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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4923
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pubmed:dateCreated |
1989-10-13
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pubmed:abstractText |
The neutrophil Mac-1 and gp100MEL-14 adhesion proteins are involved in neutrophil extravasation during inflammation. Both the expression and activity of Mac-1 are greatly increased after neutrophil activation. In contrast, neutrophils shed gp100MEL-14 from the cell surface within 4 minutes after activation with chemotactic factors or phorbol esters, releasing a 96-kilodalton fragment of the antigen into the supernatant. Immunohistology showed that gp100MEL-14 was downregulated on neutrophils that had extravasated into inflamed tissue. The gp100MEL-14 adhesion protein may participate in the binding of unactivated neutrophils to the endothelium; rapid shedding of gp100MEL-14 may prevent extravasation into and damage of normal tissues by activated neutrophils.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Chemotactic Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Complement C5,
http://linkedlifedata.com/resource/pubmed/chemical/Complement C5a,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-8,
http://linkedlifedata.com/resource/pubmed/chemical/Leukotriene B4,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Macrophage-1 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
245
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1238-41
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2551036-Animals,
pubmed-meshheading:2551036-Antigens, Differentiation,
pubmed-meshheading:2551036-Antigens, Surface,
pubmed-meshheading:2551036-Bone Marrow Cells,
pubmed-meshheading:2551036-Cell Adhesion,
pubmed-meshheading:2551036-Cell Adhesion Molecules,
pubmed-meshheading:2551036-Chemotactic Factors,
pubmed-meshheading:2551036-Complement C5,
pubmed-meshheading:2551036-Complement C5a,
pubmed-meshheading:2551036-Fluorescent Antibody Technique,
pubmed-meshheading:2551036-Interleukin-1,
pubmed-meshheading:2551036-Interleukin-8,
pubmed-meshheading:2551036-Kinetics,
pubmed-meshheading:2551036-Leukotriene B4,
pubmed-meshheading:2551036-Lipopolysaccharides,
pubmed-meshheading:2551036-Lymphocyte Activation,
pubmed-meshheading:2551036-Macrophage Activation,
pubmed-meshheading:2551036-Macrophage-1 Antigen,
pubmed-meshheading:2551036-Mice,
pubmed-meshheading:2551036-Mice, Inbred BALB C,
pubmed-meshheading:2551036-Neutrophils,
pubmed-meshheading:2551036-Tetradecanoylphorbol Acetate,
pubmed-meshheading:2551036-Tumor Necrosis Factor-alpha
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pubmed:year |
1989
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pubmed:articleTitle |
Neutrophil Mac-1 and MEL-14 adhesion proteins inversely regulated by chemotactic factors.
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pubmed:affiliation |
Department of Pathology, Stanford University, CA 94305.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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