| pubmed-article:2550939 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2550939 | lifeskim:mentions | umls-concept:C0597694 | lld:lifeskim |
| pubmed-article:2550939 | lifeskim:mentions | umls-concept:C0037492 | lld:lifeskim |
| pubmed-article:2550939 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:2550939 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:2550939 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:2550939 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:2550939 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:2550939 | pubmed:dateCreated | 1989-10-24 | lld:pubmed |
| pubmed-article:2550939 | pubmed:abstractText | Expression of the amiloride-sensitive sodium channel was examined in Xenopus oocytes that were microinjected with A6 cell mRNA. Amiloride-inhibitable 22Na flux could be measured in intact oocytes 2-3 days after injection with 25 ng of poly(A)+ RNA isolated from aldosterone-treated A6 cells. The rate of 22Na uptake was approximately 15-fold greater in oocytes microinjected with 25 ng of poly(A)+ RNA than in water-injected control oocytes. An increase in 22Na uptake by mRNA-injected oocytes occurred whether the mRNA was isolated from A6 cells grown on a porous or nonporous support. In the presence of 4 mM NaCl, amiloride caused dose-dependent inhibition of 22Na uptake in mRNA-injected oocytes, which was half-maximal at 6 x 10(-8) M. Both 1 microM amiloride and 0.1 microM benzamil inhibited 22Na uptake in mRNA-injected oocytes by greater than 95%, whereas less than 50% inhibition occurred with 1 microM 5-(N-ethyl-N-isopropyl)amiloride. When A6 cell mRNA was size fractionated by sucrose density-gradient centrifugation, amiloride-sensitive 22Na uptake was expressed predominantly by oocytes injected with mRNA from two contiguous fractions. | lld:pubmed |
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| pubmed-article:2550939 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2550939 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2550939 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2550939 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2550939 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2550939 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:2550939 | pubmed:author | pubmed-author:GeeringKK | lld:pubmed |
| pubmed-article:2550939 | pubmed:author | pubmed-author:RossierB CBC | lld:pubmed |
| pubmed-article:2550939 | pubmed:author | pubmed-author:KraehenbuhlJ... | lld:pubmed |
| pubmed-article:2550939 | pubmed:author | pubmed-author:KleymanT RTR | lld:pubmed |
| pubmed-article:2550939 | pubmed:author | pubmed-author:GeorgeA LALJr | lld:pubmed |
| pubmed-article:2550939 | pubmed:author | pubmed-author:StaubOO | lld:pubmed |
| pubmed-article:2550939 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2550939 | pubmed:volume | 86 | lld:pubmed |
| pubmed-article:2550939 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2550939 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2550939 | pubmed:pagination | 7295-8 | lld:pubmed |
| pubmed-article:2550939 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2550939 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2550939 | pubmed:articleTitle | Functional expression of the amiloride-sensitive sodium channel in Xenopus oocytes. | lld:pubmed |
| pubmed-article:2550939 | pubmed:affiliation | Department of Medicine, University of Pennsylvania, Philadelphia 19104. | lld:pubmed |
| pubmed-article:2550939 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2550939 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2550939 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:2550939 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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